생물정신의학 (Korean Journal of Biological Psychiatry)

  • 제17권3호
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  • Pages.153-160
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  • 2010
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  • 1225-8709(pISSN)
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  • 2005-7571(eISSN)
대한생물정신의학회 (The Korean Society of Biological Psychiatry)
권호 표지

양극성 장애 환자와 정상인에서 계절성의 양상과 관련 요인 탐색

Seasonal Changes in Mood and Behavior and Associated Factors of Seasonality in Korean Bipolar Disorder Patients and Normal Controls

  • 최정미 (성균관대학교 의과대학 삼성서울병원 정신과학교실) ;
  • 백지현 (성균관대학교 의과대학 삼성서울병원 정신과학교실) ;
  • 김지선 (성균관대학교 의과대학 삼성서울병원 정신과학교실) ;
  • 최지선 (삼성생명과학연구소 임상의학연구센터) ;
  • 노지혜 (삼성생명과학연구소 임상의학연구센터) ;
  • 남희정 (서울특별시 은평병원 정신과) ;
  • 이동수 (성균관대학교 의과대학 삼성서울병원 정신과학교실) ;
  • 홍경수 (성균관대학교 의과대학 삼성서울병원 정신과학교실)
  • Choi, Jungmi (Department of Psychiatry, Sungkyunkwan University School of Medicine) ;
  • Baek, Ji Hyun (Department of Psychiatry, Sungkyunkwan University School of Medicine) ;
  • Kim, Ji Sun (Department of Psychiatry, Sungkyunkwan University School of Medicine) ;
  • Choi, Ji Sun (Samsung Biomedical Research Institute, Center for Clinical Medicine) ;
  • Noh, Jihae (Samsung Biomedical Research Institute, Center for Clinical Medicine) ;
  • Nam, Hee Jung (Department of Psychiatry, Eunpyeong Hospital) ;
  • Lee, Dongsoo (Department of Psychiatry, Sungkyunkwan University School of Medicine) ;
  • Hong, Kyung Sue (Department of Psychiatry, Sungkyunkwan University School of Medicine)
  • 투고 : 2010.07.12
  • 심사 : 2010.08.03
  • 발행 : 2010.08.31
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초록

Objectives : Recurrence of mood episodes associated with a specific season has been described in various mood disorders. Seasonal change in mood and behavior as a lifetime trait is also observed in healthy individuals. This study aimed at comparing the lifetime trait of seasonal variations of mood and behavior between bipolar disorder patients and controls as well as investigating associated factors of seasonality. Methods : Subjects were ninety-four clinically stable patients with bipolar disorder and 188 age- and sex-matched healthy controls. Seasonality of mood and behavior was assessed retrospectively on lifetime basis using Seasonal Pattern Assessment Questionnaire(SPAQ). Results : The patient group showed a higher median global seasonality score(GSS) of SPAQ and a higher rate of seasonal affective disorder(SAD) compared to the control group(p < 0.0001). For subjects showing prominent seasonality, the seasonal symptom profile and seasonal pattern was similar in both patient and control groups. In addition to the diagnosis, female gender was shown to be a predictor of seasonality in the multiple linear regression analysis(p = 0.045). Conclusion : This study suggests that lifetime trait of seasonality may be related to the susceptibility of bipolar disorder.

키워드

참고문헌

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