Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Higher QT Dispersion in Patients with Social Anxiety Disorder

사회불안장애의 QT Dispersion 연구

  • Kwon, Young-Do (Department of Psychiatry, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University) ;
  • Lim, Se-Won (Department of Psychiatry, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University) ;
  • Oh, Kang-Seob (Department of Psychiatry, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University)
  • 권영도 (성균관대학교 의과대학 강북삼성병원 정신과학교실) ;
  • 임세원 (성균관대학교 의과대학 강북삼성병원 정신과학교실) ;
  • 오강섭 (성균관대학교 의과대학 강북삼성병원 정신과학교실)
  • Published : 2010.02.28
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Abstract

Objectives : Social phobia is frequently accompanied with autonomic nerve system symptoms. QT dispersion(QTd) is the maximum inter-lead difference in QT interval, an indicator of the autonomic nerve system(ANS) disparity of the heart itself. The objective of this study is to investigate the ANS disparity, which is measured by QTd, is associated with pathophysiology of social phobia. Methods : This research have compared QT dispersion of 25 physically healthy social phobia outpatients(16 men, 9 women, the average age $35.5{\pm}12.9$) and age and sex matched control group of mentally and physically healthy 25 volunteers(16 men, 9 women, the average age $34.83{\pm}12.7$). QTd was measured by previously described method. Results : QTd and rate-corrected QTd were significantly higher on the patient group than the control group[QTd(patients vs. controls : $52.60{\pm}27.63ms$ vs. $27.53{\pm}14.29ms$, p<0.0001), QTd(patients vs. controls : $55.79{\pm}27.98ms$ vs. $29.10{\pm}14.24ms$, p<0.0001)]. Conclusion : Our study showed that the patients with social phobia have higher QTd than the normal controls. These results suggest that the ANS disparity, which is measured by QTd, is associated with pathophysiology of social phobia.

Keywords

References

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