Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
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Relationship Between Serum Concentrations of Organochlorine Pesticides and Metabolic Syndrome Among Non-Diabetic Adults

  • Park, Sun-Kyun (Department of Preventive Medicine, School of Medicine, Kyungpook National University) ;
  • Son, Hyo-Kyung (Department of Preventive Medicine, School of Medicine, Kyungpook National University) ;
  • Lee, Sung-Kook (Department of Preventive Medicine, School of Medicine, Kyungpook National University) ;
  • Kang, Jung-Ho (School of Environmental Science and Engineering, POSTECH) ;
  • Chang, Yoon-Seok (School of Environmental Science and Engineering, POSTECH) ;
  • Jacobs, David R. Jr. (Division of Epidemiology, School of Public Health, University of Minnesota) ;
  • Lee, Duk-Hee (Department of Preventive Medicine, School of Medicine, Kyungpook National University)
  • Published : 2010.01.31
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Abstract

Objectives: This study was performed to investigate if organochlorine pesticides (OCPs) were associated with metabolic syndrome and insulin resistance among non-diabetes. Methods: Among subjects who participated in a community-based health survey, 50 non-diabetic subjects with metabolic syndrome and 50 normal controls were selected. Insulin resistance was measured by the homeostasis model assessment (HOMA-IR). Eight OCPs were selected. Results: After adjusting for confounders except for body mass index (BMI), beta-hexachlorocyclohexane ($\beta$-HCH) and heptachlor epoxide were positively associated with metabolic syndrome. Odds ratios across tertiles of $\beta$-HCH and heptachlor epoxide were 1.0, 3.2 and 4.4, and 1.0, 4.0 and 6.0, respectively (p for trend = 0.01 and <0.01). After additional adjustment for body mass index (BMI), heptachlor epoxide still showed an increasing trend with adjusted odds ratios of 1.0, 4.1, and 4.6 (p for trend = 0.10). When the five components of metabolic syndrome (with the definition of high fasting glucose ($\geq$ 100 mg/dL) were separately analyzed, all components were positively, but not significantly, associated with heptachlor epoxide. As the serum concentration of heptachlor epoxide increased, HOMA-IR increased significantly in subjects with metabolic syndrome even after adjusting for BMI (p value <0.05 and <0.01). Conclusions: Despite the small sample size, this study suggests that the background exposure to some OCPs may be associated with metabolic syndrome.

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