한국연초학회지 (Journal of the Korean Society of Tobacco Science)

한국연초학회 (The Korean Society of Tobacco Science)
권호 표지

담배연기 중 생물학적 활성 성분

Biological active components in cigarette mainstream smoke

  • 발행 : 2010.06.24
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초록

담배 주류연은 수천가지 종류의 다양한 형태의 화학물질로 구성되어있고, 이들 화학물질의 대부분은 극히 미량의 농도로 존재하는 것으로 알려져 있다(Green and Rodgman, 1996). 담배연기 속에서 발암물질로서는 poly cyclic aromatic hydrycarbon (PAHs) 류인 B(a)P를 최초로 보고된 이후, 현재까지 69종의 화합물이 담배연기중의 발암물질로서 알려졌으며, 여기에는 9종의 PAHs 그리고 4종의 aromatic amine, nitrosoamines 및 aldehydes 그리고 다른 무기 및 유기 화합물들을 포함된다. 또한 담배 주류연에는 여러 화학물질들에 의해 유발된 생물학적 독성을 상당히 감소시키는 것으로 확인된 성분들이 존재하는 것으로 알려져 있다. 이러한 담배연기 중에 존재하는 항 발암성 효과를 나타내는 성분들의 작용 메카니즘은 발암성 물질 또는 발암성 물질의 대사산물들과 반응을 하거나, 불활성화 시키거나, 세포 구성 물질들과의 반응에서 서로 경쟁하거나, 또는 발암성의 흡수를 간섭함으로서 발암성 효과를 없애거나 또는 감소시키는 것으로 생각된다. 여러 연구자들은 담배연기 응축물에서 종양 성장의 억제 작용을 하는 성분들이 존재하는 것으로 주장 하고 있다.(Hoffmann and Griffin, 1958; Fall et al., 1964; Homburger and Tregier, 1965). 담배 연기 중에는 발암성을 나타내는 성분들과 함께 항 발암성 및 항 돌연변이성 효과를 나타내는 성분들이 존재한다는 것이 다양한 생물학적 평가 연구들에 의해 증명되었다(Slaga and DiGivanni, 1984; Fay et al., 1984; Green and Rodgman, 1996).

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참고문헌

  1. Baker, R. R., Massey, E. D. and Smith, G. (2004) An overview of the effects of tobacco ingredients on smoke chemistry and toxicity. Food Chem. Toxicol. 42: S53-S83. https://doi.org/10.1016/j.fct.2004.01.001
  2. Brown, B., J.T. Avalos, C.K. Lee, and D.J. Doolittle (2001) The effect of tobacco smoke, nicotine, and cotinine on the mutagenicity of 4-(methylnitros-amino)-1-(3-pyridyl)-1-butanol (NNAL); 55th Tobacco Science Research Conference, Program Booklet and Abstracts, Vol. 55, Paper No. 10, p. 26.
  3. Chung, F.L., A. Juchatz, J. Vitarius, and S.S. Hecht (1984) Effects of dietary compounds on $\alpha$-hydroxylation of N-nitrosopyrrolidine and N'-nitroso-nornicotine in rat target tissues. Cancer Res. 44: 2924-2928.
  4. Chung, F.L., A. Juchatz, J. Vitarius, B. Reiss, and S.S. (1984) Hecht: Inhibition of target tissue activation of N'-nitrosonornicotine and N-nitroso-pyrrolidine by dietary components; in: N-Nitroso compounds: Occurrence, biological effects and relevance to human cancer, edited by I.K. O'Neill, R.C. von Borstel, C.T. Miller, J. Long, and H. Bartsch, IARC, Lyon, France, IARC Sci. Publ. No. 57: 797-804.
  5. Chung, F.L., M.A. Morse, K.I. Eklind, and Y. Xu (1993) Inhibition of tobacco specific nitrosamine induced lung tumorigenesis by compounds derived from cruciferous vegetables and green tea; in: Tobacco smoking and nutrition: Influence of nutrition on tobacco-associated health risks, edited by J.N. Diana and W.A. Pryor, Ann. NY Acad. Sci. 686: 186-202. https://doi.org/10.1111/j.1749-6632.1993.tb39174.x
  6. Cohen, G.M., W.P. Bracken, R.P. Iyer, D.L. Berry, and T.J. Slaga (1979) Anticarcinogenic effects of 2,3,7,8-tetrachlorodibenzo-$\rho$-dioxin on benzo-[a]pyrene and 7,12-dimethylbenz[a] anthracene tumor initiation and its relationship to DNA binding. Cancer Res. 39: 4027-4033.
  7. Cooper, R. L., Lindsey, A. J. and Wallwe, R. E. (1954) The presence of 3,4-benzopyrene in cigarette smoke. Chem. Ind. 46: 14-18. https://doi.org/10.1021/ie50537a901
  8. Crabtree, H.G. (1944) Influence of bromobenzene on the induction of skin tumors by 3,4-benzopyrene. Cancer Res. 4: 688-693.
  9. Crabtree, H.G. (1945) Influence of unsaturated di- basic acids on the induction of skin tumors by chemical carcinogens. Cancer Res. 5: 346-351.
  10. Crabtree, H.G. (1946) Some effects of aromatic hydrocarbons on sulfur metabolism and tumor induction in mice. Cancer Res. 6: 553-559.
  11. Curvall, M., Enzell, C. R. and Pettersson, B. (1984) An evaluation of the utility of four in vitro short term tests for predicting the cytotoxicity of individual compounds derived from tobacco smoke. Cell Biol. Toxicol. 1: 173-193. https://doi.org/10.1007/BF00125573
  12. DiGiovanni, J., T.J. Slaga, D.L. Berry, and M.R. Juchau (1980) Inhibitory effects of environmental chemicals on polycyclic aromatic hydrocarbon carcinogenesis; in: Carcinogenesis. A comprehensive survey. Vol. 5, edited by T.J. Slaga, Raven Press, New York, NY, p. 145-168.
  13. Dipple, A., R.C. Moschel, and C.A.H. Bigger (1984) Polynuclear hydrocarbons; Chapter 2, in: Chemical carcinogens. Second edition, edited by C.E. Searle, American Chemical Society Monograph 182, American Chemical Society, Washington, DC, p. 41-163.
  14. Doll, R., and Hill, A. B. (1950) Smoking and carcinoma of the lung: Preliminary report. Br. Med. J. II, 739-748.
  15. Dontenwill, W., Chevalier, H. J., Harke, H.-P., Lafrenz, U., Reckzeh, G., and Schneider, B. (1973) Investigation of the effects of chronic cigarette smoke inhalation in Syrian golden hamsters. J. Natl. Cancer Inst. 51: 1781-1832. https://doi.org/10.1093/jnci/51.6.1781
  16. Eatough, D.J., L.D. Hansen, and E.A. Lewis (1989) The chemical characteriza- tion of environmental tobacco smoke; in: Environmental tobacco smoke, edited by D.J. Ecobichon and J.M. Wu, Proc. International Symposium at McGill University, PQ, Canada, Lexington Books, D.C. Heath and Company, Lexington, MA, 1990, p. 3-39.
  17. Falk, H.L., P. Kotin, and S. Thompson (1964) Inhibition of carcinogenesis. The effect of hydrocarbons and related compounds. Arch. Environ. Hlth. 9: 169-179. https://doi.org/10.1080/00039896.1964.10663816
  18. Fay, J.R., L.R. Perry, L.A. Kanerva, C.C. Sigman, and C.T. Helmes (1984). Inhibitors of chemical carcinogenesis; Document prepared in 1984, revised in 1985 for Sci. Coordinator Environ. Cancer, National Cancer Institute, Bethesda, MD, 1985, p. 1-96.
  19. Green, C.R. (1977a) Some relationships between tobacco leaf and smoke composition. In: Proc. 173rd Am. Chem. Soc. Symp., Rec. Adv. Chem. Comp. Tob. Tob. Smoke. p. 426-70.
  20. Green, C.R. (1977b) Neutral oxygenated compounds in cigarette smoke and their possible precursors. Rec. Adv. Tob. Sci. 3: 94-120.
  21. Green, C. R. and Rodgman, A. (1996) The tobacco chemists research conference: a half century forum for advances in analytical methodology of tobacco and its products. Rec. Adv. Tob. Sco. 22: 131-304.
  22. Hecht, S.S., Schmeltz, I. and Hoffmann, D. (1977) Nitrogenous compounds in cigarette smoke and their possible precursors. Rec. Adv. Tob. Sci. 3: 59-93.
  23. Hoffman, H.E. and A.C. Griffin (1958) Action of cigarette tar and smoke on chemically induced carcinogenesis. Texas Rep. Biol. Med. 16: 333-345.
  24. Hoffmann, D. and E.L. Wynder (1962) A study of air pollution carcinogens. II. The isolation and identification of polynuclear aromatic hydrocarbons from gasoline engine exhaust condensate. Cancer 15: 93-102. https://doi.org/10.1002/1097-0142(196201/02)15:1<93::AID-CNCR2820150113>3.0.CO;2-G
  25. Homburger, F. and A. Treger (1965) Effects of intravenous carcinogen and tobacco condensate injections upon the incidence of lung tumors in A/He mice; in: Lung tumors in animals, edited by L. Severi, Division of Cancer Research, University of Perugia, Italy, pp. 527-536.
  26. Homburger, F., A. Treger, and E. Boger (1971) Inhibition of murine subcutane- ous and intravenous benzopentaphene carcinogenesis by sweet orange oils and D-limonene. Oncology 25: 1-10. https://doi.org/10.1159/000224548
  27. International Agency for Research on Cancer (IARC) (1985) Chemistry and analysis of tobacco smoke. In: IARC Monograph on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Volume 38, Tobacco Smoking pp. 83-126. IARC, Lyon.
  28. Ishiguro, S., and Sugawara, S. (1986) The Chemistry of Tobacco Smoke (in Japanese) Central Institute, Japanese Tobacco Monopoly Corporation, Yokahama, Japan, p. 202 (English translation (1981), p. 247).
  29. Izard, C., J. LaCharpagne, and P. Testa (1966) Sur l'activite biologique de divers condensats de fumee de cigarettes, revelee par les tests auxiniques [On the biological activity disclosed in cellular tests of different cigarette smoke condensates]; Compt. Rend. 262D: 1859-1861.
  30. Johnstone, R. A. W. and Plimmer, J. R. (1959) The chemical constituents of tobacco and tobacco smoke. Chemical Review 59: 885-936. https://doi.org/10.1021/cr50029a004
  31. Keith, C.H. and Tesh, P.G. (1965) Measurement of the total smoke issuing from a burning cigarette. Tob. Sci. 9: 61-64.
  32. Lee, C.K. and E.A. Reed (1983) Ames test on smoke condensates: A summary; RJRT R&DM, No. 20, May 9, see www.rjrtdocs.com 508352301-2303.
  33. Lee, C.K., J.A. Munoz, C.W. Fulp, K.M. Chang, J. Rogers, M.F. Borgerding, and D.J. Doolittle (1993) Inhibitory activity of cigarette-smoke condensate on the mutagenicity of heterocyclic amines. Mutat. Res. 322: 21-32.
  34. Lee, C.K., C.W. Fulp, D.W. Bombick, and D.J. Doolittle (1996) Inhibition of mutagenicity of N-nitrosamines by tobacco smoke and its constituents. Mutat. Res. 367: 83-92. https://doi.org/10.1016/0165-1218(95)00078-X
  35. Manabe, S. and Wada, O. (1990) Carcinogenic tryptophan pyrolysis products in cigarette smoke condensate and cigarette smoke-polluted indoor air. Environ. Pollute. 64: 121-132. https://doi.org/10.1016/0269-7491(90)90109-P
  36. Murphy, S.E. and R. Heilbrun (1990) Effect of nicotine and tobacco-specific nitrosamines on the metabolism of N'-nitrosonornicotine and 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone by rat oral tissue. Carcinogenesis 11: 1663-1666. https://doi.org/10.1093/carcin/11.9.1663
  37. Norman, V. (1977) An overview of the vapor phase, semivolatile and nonvolatile components of cigarette smoke. Rec. Adv. Tob. Sci. 3: 8-58.
  38. Phillips, D. H. (2002) Smoking-related DNA and protein adducts in human tissues. Carcinogenesis 23: 1979-2004. https://doi.org/10.1093/carcin/23.12.1979
  39. Ramel, C., U.K. Alekperov, B.N. Ames, T. Kada, and L.W. Wattenberg (1986) Inhibitors of mutagenesis and their relevance to carcinogenesis; Report by ICPEMC Expert Group on Antimutagens and Desmutagens; Mutat. Res. 168: 47-65. https://doi.org/10.1016/0165-1110(86)90021-7
  40. Roberts, D. L. Natural tobacco flavor (1988) Recent Adv. Tob. Sci. 14, 49-81.
  41. Rodgman, A. The analysis of cigarette smoke condensate. II. The pretreatment of Camel blend tobacco; RDR, (1956) No. 12, November 1, see www.rjrtdocs.com 501008294-8336
  42. Rodgman, A. The analysis of cigarette smoke condensate. III. Flue-cured tobacco; RDR, 1957, No. 4, March 14, see www.rjrtdocs.com 501008337-8377.
  43. Rodgman, A. and L.C. Cook (1960) The composition of cigarette smoke. IV. $\alpha$-Tocopherol. Rec. Adv. Tob. Sci. 4: 7-8.
  44. Rodgman, A. and L.C. Cook (1962) The composition of cigarette smoke. XI. Heterocyclic nitrogen compounds from Turkish tobacco smoke. Rec. Adv. Tob. Sci. 6: 176-179.
  45. Rodgman, A. (1991) A comparison of the chemical and physical properties of cigarette mainstream smoke (MS), cigarette sidestream smoke (SS), and environmental tobacco smoke (ETS); Document submitted to the Environmental Protection Agency, December, Revised version submitted, June, pp. i-vii + 1-117, see www.rjrtdocs.com 508185686-5809.
  46. Rodgman, A. (1994) The chemical composition of environmental tobacco smoke: Some comments on the Occupational Safety and Health Administration's notice on 'Indoor Air Quality' Document submitted to the Occupational Safety and Health Administration, 5 August, pp. i-xiii, 1-172, see www.rjrtdocs.com 515923456-645; 515926645-6833.
  47. Rodgman, A. (2001) Studies of polycyclic aromatic hydro-carbons in cigarette mainstream smoke: Identification, tobacco precursors, control of levels: A review. Beitr. Tabakforsch. Int. 19: 361-379.
  48. Schuller, H.M., A. Castonguay, M. Orloff, and G. Rossignol (1991) Modulation of the uptake and metabolism of 4-(N-methylnitrosamino)-1-(3-pyridyl)- 1-butanone by nicotine. Cancer Res. 51: 2009-2114.
  49. Slaga, T.J. and R.K. Boutwell (1977) Inhibition of the tumor-initiating ability of the potent carcinogen 7,12-dimethylbenz[a]anthracene by the weak tumor initiator 1,2,3,4-dibenzanthracene; Cancer Res. 37: 129-133.
  50. Slaga, T.J., A. Viaje, S.G. Buty, and W.M. Bracken (1978) Dibenz[a,c]- anthracene: A potent inhibitor of skin-tumor initiation by 7,12-dimethyl-benz-[a]anthracene; Res. Comm. Chem. Pathol. Pharmacol. 19: 477-483.
  51. Slaga, T.J., L. Jecker, W.M. Bracken, and C.E. Weeks (1979) The effects of weak or non-carcinogenic polycyclic hydrocarbons on 7,12-dimethylbenz- [a]anthracene and benzo [a]pyrene; Cancer Lett. 7: 51-59. https://doi.org/10.1016/S0304-3835(79)80076-2
  52. Slaga, T.J. and J. DiGiovanni (1984) Inhibition of chemical carcinogenesis; Chapter 21, in: Chemical carcinogens. Second edition, edited by C.E. Searle, American Chemical Society Monograph 182, American Chemical Society, Washington, DC, p. 1279-1321.
  53. Steiner, P.E. and H.L. Falk (1951) Summation and inhibition effects of weak and strong carcinogenic hydrocarbons, 1:2-benzanthracene, chrysene, 1:2:5:6-dibenzanthracene, and 20-methylcholanthrene; Cancer Res. 11: 56-63.
  54. Stedman, R. L. (1968) The chemical composition of tobacco and tobacco smoke. Chem. Rev. 68: 153-207. https://doi.org/10.1021/cr60252a002
  55. Stedman, R. L. (1968) The chemical composition of tobacco and tobacco smoke. Chemical Review 68: 153-207. https://doi.org/10.1021/cr60252a002
  56. Takeda, K., S. Ukawa, and M. Mochizuki (1991) Inhibition by fatty acids of direct mutagenicity of N-nitroso compounds in: Relevance to human cancer of N-nitroso compounds, tobacco and mycotoxins, edited by I.K. O'Neill, J. Chen, and H. Bartsch, IARC, Lyon, France, IARC Sci. Publ. No. 105: 558-563.
  57. Teel, R. and A. Castonguay (1992) Antimutagenic effects of polyphenolic compounds. Cancer Lett. 66: 107-113. https://doi.org/10.1016/0304-3835(92)90222-H
  58. Thompson, H. J (1991) Effect of deficiencies of selenium and vitamin E alone or in combination on the induction of mammary carcinogenesis by 1-methyl-1-nitrosourea. Carcinogenesis 12: 2175-2179. https://doi.org/10.1093/carcin/12.11.2175
  59. Thomson, H. V. (1992) International reference method for the smoking of cigarettes. Rec. Adv. Tob. Sci. 18: 69-94
  60. Van Duuren, B.L., A. Sivak, C. Katz, and S. Melchionne (1971) Cigarette smoke carcinogenesis: Importance of tumor promoters; J. Natl. Cancer Inst. 47: 235-240.
  61. Waddell, W. and C. Marlowe (1983) Inhibition by alcohols of the localization of radioactive nitrosonornicotine in sites of tumor formation. Science 221: 51-52. https://doi.org/10.1126/science.6857261
  62. Wattenberg, L.W. (1981) Inhibitors of chemical carcinogens; in: Cancer: Achievements, challenges and prospects for the 1980's, edited by J.H. Burchenal, Grune and Stratton, New York, NY, pp. 517-539.
  63. Wattenberg, L.W. and J.B. Coccia (1991) Inhibition of 4-methylnitrosam ino-1-(3-pyridyl)-1-butanone carcinogenesis in mice by D-limonene and citrus fruit oils. Carcinogenesis 12: 115-117. https://doi.org/10.1093/carcin/12.1.115
  64. Williams, D., F.J. Wiebel, J.C. Leutz, and H.V. Gelboin. (1971) Effect of polycyclic hydrocarbons in vitro on aryl hydrocarbon (benzo[a]pyrene) hydroxylase. Biochem. Pharmacol. 20: 2130. https://doi.org/10.1016/0006-2952(71)90427-8
  65. Wynder, E. L., and Graham, E. A. (1950) Tobacco smoking as a possible etiologic factor in bronchiogenic carcinoma. A study of six hundred and eighty-four proven cases. J. Am. Med. Assoc. 143: 329-336. https://doi.org/10.1001/jama.1950.02910390001001
  66. Wynder, E. L., Graham, E. A., and Croninger, A. B. (1953) Experimental production of carcinoma with cigarette tar. Cancer Res. 13: 855-864.
  67. Wynder, E. L., Kopf, P, and Ziegler, H. (1957) A study of tobacco carcinogenesis. II. Dose-response studies. Cancer 10: 1193-1200. https://doi.org/10.1002/1097-0142(195711/12)10:6<1193::AID-CNCR2820100616>3.0.CO;2-Y
  68. Wynder, E.L. and D. Hoffmann (1959) A study of tobacco carcinogenesis. VII. The role of higher polycyclic hydrocarbons. Cancer 12: 1079-1086. https://doi.org/10.1002/1097-0142(195911/12)12:6<1079::AID-CNCR2820120604>3.0.CO;2-I
  69. Wynder, E.L. and D. Hoffmann (1961) Biological and chemical studies of tobacco smoke condensate. Proc. Am. Assoc. Cancer Res. 3: 280.
  70. Wynder. E.L. and D. Hoffmann (1962) Studies with the gaseous and particulate phase of tobacco smoke. Proc. Am. Assoc. Cancer Res. 3: 373.
  71. Wynder, E.L. and D. Hoffmann (1967) Tobacco and tobacco smoke: Studies in experimental carcinogenesis. Academic Press, New York, NY.