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  • 제10권2호
  • /
  • Pages.64-74
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  • 2010
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  • 1598-2629(pISSN)
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  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
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Polybrominated Diphenyl Ethers Orally Administration to Mice Were Tansferred to Offspring during Gestation and Lactation with Disruptions on the Immune System

  • Hong, Soon-Keun (Immnotoxicity Division, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Sohn, Kyung-Hee (Immnotoxicity Division, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Kim, In-Young (Immnotoxicity Division, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Lee, Jong-Kwon (Immnotoxicity Division, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Ju, Jung-Hun (Immnotoxicity Division, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Kim, Jin-Ho (Immnotoxicity Division, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Lim, Chae-Hyung (Immnotoxicity Division, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Han, Beom-Seok (Immnotoxicity Division, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Jung, Hwa-Chul (Immnotoxicity Division, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Lee, Jin-Yong (Immnotoxicity Division, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Park, Kui-Lea (Immnotoxicity Division, National Institute of Toxicological Research, Korea Food and Drug Administration)
  • 투고 : 2010.02.05
  • 심사 : 2010.04.13
  • 발행 : 2010.04.30
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초록

Background: The present study was undertaken to examine the immunological effects of pentabrominated diphenyl ether (penta-BDE) and decabrominated diphenyl ether (deca-BDE) on the immune system of the dams and the developmental immune system of the offsprings. Methods: In this study, mated female C57BL/6J mice were orally administered penta-BDE, deca-BDE or corn oil for 5 weeks, from gestational day 6 to lactational day 21. Results: The body weight of PND21 exposed to penta-BDE was significantly decreased relative to control mice, but that of post-natal day 63 (PND63) were recovered. Orally dosed dams with penta-BDE had significantly smaller absolute and relative spleen masses than control mice. Absolute and relative spleen and thymus masses of PND21 exposed to penta-BDE were significantly decreased over control. The exposure of dams and PND21 with penta-BDE reduced the number of splenocytes and thymocytes. As results of hematologic analysis, percentage WBC and percentage neutrophils increased in dams with deca-BDE. Splenic T cell proliferation in dams and PND21 exposed to penta-BDE was increased, and there were no significant difference in splenic B cell proliferation in all treatment groups. As results of flow cytometric analysis of splenocyte, percentage total T cell, Th cell and Tc cell in PND21 exposed to penta-BDE was slightly increased, and percentage macrophage in dams and PND21 exposed to deca-BDE was decreased. The ELISA results of antibody production show no significant difference in all treatment groups relative to controls. Conclusion: These results imply that PBDEs given to the dam were transferred to the offspring during gestation and lactation, and PBDEs transferred from the dam affect immune system of offspring.

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참고문헌

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