Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Portal Vein Thrombosis in a Dog with Dirofilariasis

심장사상충에 감염된 개에서 발생한 문정맥혈전증

  • Yun, Seok-Ju (College of Veterinary Medicine, Chungbuk National University) ;
  • Cheon, Haeng-Bok (College of Veterinary Medicine, Chungbuk National University) ;
  • Han, Jae-Ik (College of Veterinary Medicine, Chungbuk National University) ;
  • Kang, Ji-Houn (College of Veterinary Medicine, Chungbuk National University) ;
  • Chang, Jin-Hwa (College of Veterinary Medicine, Chungbuk National University) ;
  • Na, Ki-Jeong (College of Veterinary Medicine, Chungbuk National University) ;
  • Chang, Dong-Woo (College of Veterinary Medicine, Chungbuk National University)
  • Accepted : 2010.09.16
  • Published : 2010.10.30
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Abstract

A ten-year-old female mongrel dog was presented to Veterinary Medical Center, Chungbuk National University with the signs of anorexia, weakness, and hemoglobinuria. Patient had been diagnosed as dirofilariasis based on heartworm antigen test and treated with adulticide (melarsomine) at local hospital one day before admission. On laboratory examinations, there were hypochromic and microcytic regenerative anemia, thrombocytopenia, moderate neutrophilia, and increase ALT, AST, and ALP. Radiographic exam showed main pulmonary artery bulging, pulmonary infiltration and hypervascularity, reduced abdominal serosal detail and mild hepatomegaly. Abdominal ultrasonographic exam showed mild peritoneal effusion and large hyperechoic thrombi at trifurcation of the porta hepatica and the splenic vein. In addition, intraluminal low density area and intravascular filling defect were confirmed on contrast enhanced CT scanning at the same anatomic locations. Patient was treated with anticoagulant and thrombolytic therapy. On day 42 after treatment, complete resolution of thrombi was confirmed via ultrasonography and improvement of clinical signs was observed.

10년령의 암컷 잡종견이 식욕부진, 쇠약, 혈색소뇨를 주증으로 충북대학교 동물의료센터에 내원하였다. 환자는 내원 하루 전 지역동물병원에서 효소 면역 측정법에 의해 심장사상충증을 진단 받았으며 성충구제제를 투여 받았다. 혈액검사를 통해 저색소성 소적혈구성 재생성 빈혈과 혈소판감소증, 중등도의 호중구증가증, ALT AST ALP의 상승이 확인되었다. 방사선 촬영을 통해 주페동맥의 확장, 폐침윤, 복부 선예도 감소, 경증의 간비대가 확인되었다. 복부 초음파 검사에서 경증의 복수, 간문 수준의 문정맥과 비장정맥에서 고에코성의 혈전이 확인되었다. 조영 증강 컴퓨터 단층촬영을 통해 문정맥 내강내 저밀도 영역과 혈관내 충진결손을 확인하였다. 환자는 항응고제와 혈전용해제로 치료를 받았으며, 42일 동안의 치료 후 혈전의 완전한 용해를 복부 초음파 검사를 통해 확인하였으며 임상 증상의 개선이 관찰되었다.

Keywords

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