Genomics & Informatics

Korea Genome Organization (한국유전체학회)
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Classification of Biological Effect of 1,763 MHz Radiofrequency Radiation Based on Gene Expression Profiles

  • Im, Chang-Nim (Genomics Core Laboratory and Departments of Biochemistry and Molecular Biology, Seoul National University College of Medicine) ;
  • Kim, Eun-Hye (Genomics Core Laboratory and Departments of Biochemistry and Molecular Biology, Seoul National University College of Medicine) ;
  • Park, Ae-Kyung (Genomics Core Laboratory and Departments of Biochemistry and Molecular Biology, Seoul National University College of Medicine) ;
  • Park, Woong-Yang (Genomics Core Laboratory and Departments of Biochemistry and Molecular Biology, Seoul National University College of Medicine)
  • Published : 2010.03.31
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Abstract

Radiofrequency (RF) radiation might induce the transcription of a certain set of genes as other physical stresses like ionizing radiation and UV. To observe transcriptional changes upon RF radiation, we exposed WI-38, human lung fibroblast cell to 1763 MHz of mobile phone RF radiation at 60 W/kg of specific absorption rate (SAR) for 24h with or without heat control. There were no significant changes in cell numbers and morphology after exposure to RF radiation. Using quantitative RT-PCR, we checked the expression of three heat shock protein (HSP) (HSPA1A, HSPA6 and HSP105) and seven stress-related genes (TNFRSF11B, FGF2, TGFB2, ITGA2, BRIP1, EXO1, and MCM10) in RF only and RF/HS groups of RF-exposed cells. The expressions of three heat shock proteins and seven stress-related genes were selectively changed only in RF/HS groups. Based on the expression of ten genes, we could classify thermal and non-thermal effect of RF-exposure, which genes can be used as biomarkers for RF radiation exposure.

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References

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