The Comparison of the Effects of Nicardipine and Remifentanil on Fluctuation of Blood Pressure during Controlled Hypotension

유도 저혈압하 양악 교정술 시 Nicardipine과 Remifentanil의 혈역학적 비교

  • Kim, Eun-Soo (Department of Anesthesia and Pain Medicine, School of Medicine, Pusan National University) ;
  • Hwang, Boo-Young (Department of Anesthesia and Pain Medicine, School of Medicine, Pusan National University) ;
  • Kim, Cheul-Hong (Department of Anesthesia and Pain Medicine, School of Dentistry, Pusan National University)
  • 김은수 (부산대학교 의학전문대학원 마취통증의학교실) ;
  • 황부영 (부산대학교 의학전문대학원 마취통증의학교실) ;
  • 김철홍 (부산대학교 치의학전문대학원 치과마취통증학교실)
  • Received : 2010.12.06
  • Accepted : 2010.12.21
  • Published : 2010.12.31

Abstract

Background: Controlled hypotension is used to reduce bleeding and improve surgical conditions during surgery. Nicardipine and remifentanil have been used to induce controlled hypotension in healthy patients. This study compared controllability of nicardipine and remifentanil on hemodynamic stability during controlled hypotension. Methods: Forty healthy patients scheduled for orthognathic two jaw surgery were randomly allocated to nicardipine (group N) and remifentanil (group R) group. After induction of anesthesia, group N (n = 20) was infused with nicardipine to induce hypotension and group R (n = 20) was infused with remifentanil. Mean arterial pressure (MAP) and heart rate (HR) were measured over 5 minute interval. Surgical field rating and blood loss were measured after surgery. Results: HR was lower in group R than group N. MAP was maintained at 50-60 mmHg during controlled hypotension but the fluctuation of blood pressure and HR were more frequent in group N than group R. There were no significant differences in the surgical field rating and blood loss between the groups. Conclusions: Nicardipine and remifentanil enabled controlled hypotension and provided good surgical conditions, but the fluctuation of hemodynamic parameters was more frequent in nicardipine group.

Keywords

References

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