Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
권호 표지
DOI QR코드

DOI QR Code

Neonatal respiratory distress: recent progress in understanding pathogenesis and treatment outcomes

  • Kim, So Young (Department of Pediatrics, The Catholic University of Korea, School of Medicine)
  • Received : 2009.12.02
  • Accepted : 2009.12.16
  • Published : 2010.01.15
Download PDF
⟨ Previous Next ⟩

Abstract

Transient tachypnea of the newborn (TTN), respiratory distress syndrome (RDS), and persistent pulmonary hypertension of the newborn (PPHN) are the three most common disorders that cause respiratory distress after birth. An understanding of the pathophysiology of these disorders and the development of effective therapeutic strategies is required to control these conditions. Here, we review recent papers on the pathogenesis and treatment of neonatal respiratory disease.

Keywords

References

  1. Avery ME, Gatewood OB, Brumley G. Transient tachypnea of newborn. Possible delayed resorption of fluid at birth. Am J Dis Child 1966;111:380-5
  2. Kasap B, Duman N, Ozer E, Tatli M, Kumral A, Ozkan H. Transient tachypnea of the newborn: predictive factor for prolonged tachypnea. Pediatr Int 2008;50:81-4 https://doi.org/10.1111/j.1442-200X.2007.02535.x
  3. Whitsett JA, Weaver TE. Hydrophobic surfactant proteins in lung function and disease. N Engl J Med 2002;347:2141-8 https://doi.org/10.1056/NEJMra022387
  4. Peterson SW. Understanding the sequence of pulmonary injury in the extremely low birth weight, surfactant-deficient infant. Neonatal Netw 2009;28:221-9
  5. Konduri GG, Kim UO. Advances in the diagnosis and management of persistent pulmonary hypertension of the newborn. Pediatr Clin North Am 2009;56:579-600 https://doi.org/10.1016/j.pcl.2009.04.004
  6. Kinsella JP, Abman SH. Recent developments in the pathophysiology and treatment of persistent pulmonary hypertension of the newborn. J Pediatr 1995;126:853-64 https://doi.org/10.1016/S0022-3476(95)70197-4
  7. Abman SH. Recent advances in the pathogenesis and treatment of persistent pulmonary hypertension of the newborn. Neonatology 2007;91:283-90 https://doi.org/10.1159/000101343
  8. Bell EF, Acarregui MJ. Restricted versus liberal water intake for preventing morbidity and mortality in preterm infants. Cochrane Database Syst Rev 2008;23:CD000503
  9. Brion LP, Soll RF. Diuretics for respiratory distress syndrome in preterm infants. Cochrane Database Syst Rev 2008;23: CD001454 https://doi.org/10.1002/14651858.CD001454.pub2.
  10. Riskin A, Abend-Weinger M, Riskin-Mashiah S, Kugelman A, Bader D. Cesarean section, gestational age, and transient tachypnea of the newborn: timing is the key. Am J Perinatol 2005;22:377-82 https://doi.org/10.1055/s-2005-872594
  11. Van Marter LJ, Allred EN, Pagano M, Sanocka U, Parad R, Moore M, et al. Do clinical markers of barotrauma and oxygen toxicity explain interhospital variation in rates of chronic lung disease? The Neonatology Committee for the Developmental Network. Pediatrics 2000;105:1194-201 https://doi.org/10.1542/peds.105.6.1194
  12. Brownfoot FC, Crowther CA, Middleton P. Different corticosteroids and regimens for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev 2008;8:CD006764
  13. Committee on Fetus and Newborn. Postnatal corticosteroids to treat or prevent chronic lung disease in preterm infants. Pediatrics 2002;109:330-8 https://doi.org/10.1542/peds.109.2.330
  14. Verder H, Albertsen P, Ebbesen F, Greisen G, Robertson B, Bertelsen A, et al. Nasal continuous positive airway pressure and early surfactant therapy for respiratory distress syndrome in newborns less than 30 weeks' gestation. Pediatrics 1999;103:e24 https://doi.org/10.1542/peds.103.2.e24
  15. Ho JJ, Subramaniam P, Henderson-Smart DJ, Davis PG. Continuous distending pressure for respiratory distress syndrome in preterm infants. Cochrane Database Syst Rev 2000;(4):CD002271
  16. Wintermark P, Tolsa JF, Van Melle G, Forcada-Guex M, Moessinger AC. Long-term outcome of preterm infant treated with nasal continuous positive airway pressure. Eur J Pediatr 2007;166:473-83 https://doi.org/10.1007/s00431-006-0272-3
  17. De Paoli AG, Davis PG, Lemyre B. Nasal continuous positive airway pressure versus nasal intermittent positive pressure ventilation for preterm neonates: a systematic review and meta-analysis. Acta Paediatr 2003;92:70-5 https://doi.org/10.1111/j.1651-2227.2003.tb00472.x
  18. Bolivar JM, Gerhardt T, Gonzalez A, Hummler H, Claure N, Everett R, et al. Mechanisms for episodes of hypoxemia in preterm infants undergoing mechanical ventilation. J Pediatr 1995;127:767-73 https://doi.org/10.1016/S0022-3476(95)70171-0
  19. Greenough A, Dimitriou G, Prendergast M, Milner AD. Synchronized mechanical ventilation for respiratory support in newborn infants. Cochrane Database Syst Rev 2008;23:CD000456 https://doi.org/10.1002/14651858.CD000456.pub3
  20. Ramanathan R. Synchronized intermittent mandatory ventilation and pressure support: to sync or not to sync? Pressure support or no pressure support? J Perinatol 2005;25 Suppl2:S23-5 https://doi.org/10.1038/sj.jp.7211314
  21. Patel DS, Rafferty GF, Lee S, Hannam S, Greenough A. Work of breathing during SIMV with and without pressure support. Arch Dis Child 2009;94:434-6 https://doi.org/10.1136/adc.2008.152926
  22. Osorio W, Claure N, D'Ugard C, Athavale K, Bancalari E. Effects of pressure support during an acute reduction of synchronized intermittent mandatory ventilation in preterm infants. J Perinatol 2005;25:412-6 https://doi.org/10.1038/sj.jp.7211303
  23. Reyes ZC, Claure N, Tauscher MK, D'Ugard C, Vanbuskirk S, Bancalari E. Randomized, controlled trial comparing synchronized intermittent mandatory ventilation and synchronized intermittent mandatory ventilation plus pressure support in preterm infants. Pediatrics 2006;118:1409-17 https://doi.org/10.1542/peds.2005-2923
  24. Singh J, Sinha SK, Clarke P, Byrne S, Donn SM. Mechanical ventilation of very low birth weight infants: is volume or pressure a better target variable? J Pediatr 2006;149:308-13 https://doi.org/10.1016/j.jpeds.2006.01.044
  25. Herrera CM, Gerhardt T, Claure N, Everett R, Musante G, Thomas C, et al. Effects of volume-guaranteed synchronized intermittent mandatory ventilation in preterm infants recovering from respiratory failure. Pediatrics 2002;110:529-33 https://doi.org/10.1542/peds.110.3.529
  26. Shah S. Is elective high frequency oscillatory ventilation better than conventional mechanical ventilation in very low birth weight infants? Arch Dis Child 2003;88:833-4 https://doi.org/10.1136/adc.88.9.833
  27. Henderson-Smart DJ, Cools F, Bhuta T, Offringa M. Elective high frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants. Cochrane Database Syst Rev 2007;18:CD000104
  28. Kinsella JP, Cutter GR, Walsh WF, Gerstmann DR, Bose CL, Hart C, et al. Early inhaled nitric oxide therapy in premature newborns with respiratory failure. N Engl J Med 2006;355:354-64 https://doi.org/10.1056/NEJMoa060442
  29. Mestan KK, Marks JD, Hecox K, Huo D, Schreiber MD. Neurodevelopmental outcomes of premature infants treated with inhaled nitric oxide. N Engl J Med 2005;353:23-32 https://doi.org/10.1056/NEJMoa043514
  30. Van Meurs KP, Wright LL, Ehrenkranz RA, Lemons JA, Ball MB, Poole WK, et al. Inhaled nitric oxide for premature infants with severe respiratory failure. N Engl J Med 2005;353:13-22 https://doi.org/10.1056/NEJMoa043927
  31. Engle WA: American Academy of Pediatrics Committee on Fetus and Newborn. Surfactant-replacement therapy for respiratory distress in the preterm and term neonate. Pediatrics 2008;121:419-32 https://doi.org/10.1542/peds.2007-3283
  32. Yost CC, Soll RF. Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome. Cochrane Database Syst Rev 2000;2:CD001456
  33. Soll RF. Prophylactic natural surfactant extract for preventing morbidity and mortality in preterm infants. Cochrane Database Syst Rev. 2000;2:CD000511
  34. Speer CP, Robertson B, Curstedt T, Halliday HL, Compagnone D, Gefeller O, et al. Randomized European multicenter trial of surfactant replacement therapy for severe neonatal respiratory distress syndrome: single versus multiple doses of Curosurf. Pediatrics 1992;89:13-20
  35. Kinsella JP, Truog WE, Walsh WF, Goldberg RN, Bancalari E, Mayock DE, et al. Randomized, multicenter trial of inhaled nitric oxide and high-frequency oscillatory ventilation in severe, persistent pulmonary hypertension of the newborn. J Pediatr 1997;131:55-62 https://doi.org/10.1016/S0022-3476(97)70124-0
  36. Kinsella JP, Abman SH. Inhaled nitric oxide and high frequency oscillatory ventilation in persistent pulmonary hypertension of the newborn Eur J Pediatr 1998;157:S28-30 https://doi.org/10.1007/PL00014288
  37. Lotze A, Mitchell BR, Bulas DI, Zola EM, Shalwitz RA, Gunkel JH. Multicenter study of surfactant (beractant) use in the treatment of term infants with severe respiratory failure. J Pediatr 1998;132:40-7 https://doi.org/10.1016/S0022-3476(98)70482-2
  38. Clark RH, Kueser TJ, Walker MW, Southgate WM, Huckaby JL, Perez JA, et al. Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. Clinical Inhaled Nitric Oxide Research Group. N Engl J Med 2000;342:469-74 https://doi.org/10.1056/NEJM200002173420704
  39. Kinsella JP, Cutter GR, Walsh WF, Gerstmann DR, Bose CL, Hart C, et al. Early inhaled nitric oxide therapy in premature newborns with respiratory failure. N Engl J Med 2006;355:354-64 https://doi.org/10.1056/NEJMoa060442
  40. Mestan KK, Marks JD, Hecox K, Huo D, Schreiber MD. Neurodevelopmental outcomes of premature infants treated with inhaled nitric oxide. N Engl J Med 2005;353:23-32 https://doi.org/10.1056/NEJMoa043514

Cited by

  1. 선천성 결장 폐쇄증의 경험 vol.18, pp.2, 2012, https://doi.org/10.13029/jkaps.2012.18.2.68
  2. Association between Respiratory Disorders and Candidate Genes in Korean Newborn Infants vol.20, pp.3, 2010, https://doi.org/10.5385/nm.2013.20.3.311
  3. Invasive mechanical ventilation in the delivery room: is it always worthwhile? vol.63, pp.5, 2018, https://doi.org/10.17116/anaesthesiology201805144