Dementia and Neurocognitive Disorders (대한치매학회지)

Korean Dementia Association (대한치매학회)
권호 표지

Elevated Remnant Lipoprotein Cholesterol in Patients with Alzheimer' Disease and Vascular Dementia: A Pilot Study

알츠하이머병 및 혈관성치매 환자에서 렘난트양지질단백콜레스테롤의 증가: 예비 연구

  • Shim, Yong-S. (Department of Neurology, The Catholic University of Korea School of Medicine) ;
  • Shim, Dong-Suk (Department of Neurology, The Catholic University of Korea School of Medicine) ;
  • Yoon, Bo-Ra (Department of Neurology, Konyang University School of Medicine) ;
  • Shin, Hye-Eun (Department of Neurology, The Catholic University of Korea School of Medicine) ;
  • Park, Sang-Hi (The institute of Clinical Medical Research of Bucheon St. Mary’ Hospital, The Catholic University of Korea School of Medicine) ;
  • Kang, Ji-Min (Department of Laboratory Medicine, The Catholic University of Korea School of Medicine) ;
  • Yang, Dong-Won (Department of Neurology, The Catholic University of Korea School of Medicine)
  • 심용수 (가톨릭대학교 의과대학 신경과학교실) ;
  • 심동석 (가톨릭대학교 의과대학 신경과학교실) ;
  • 윤보라 (건양대학교 의과대학 신경과학교실) ;
  • 신혜은 (가톨릭대학교 의과대학 신경과학교실) ;
  • 박상희 (가톨릭대학교 부천성모병원 임상의학연구소) ;
  • 강지민 (가톨릭대학교 의과대학 진단검사의학교실) ;
  • 양동원 (가톨릭대학교 의과대학 신경과학교실)
  • Published : 2010.09.30
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Abstract

Background: Cerebrovascular disease has been suggested as one of the mechanisms to explain the pathogenesis of Alzheimer' disease (AD) as well as vascular dementia (VaD). Although remnant lipoprotein (RLP) is strongly atherogenic and known as an independent risk factor of cardiovascular disease, there are few studies on the role in cerebrovascular disease. We conducted this study to evaluate the association between RLP and dementia, in terms of vascular etiology. Methods: Subjects were classified into 3 groups of control, AD and VaD. Plasma RLP cholesterol (RLP-C) concentrations were measured by the immunoseparation method. A total of 173 participants, who were 87 ADs, 28 VaDs, and 58 controls, were analyzed and age-matched. Results: RLP-C level was elevated in VaD (11.95${\pm}$6.67 mg/dL) and AD (10.04${\pm}$5.90 mg/dL) groups more than in control (6.31${\pm}$5.18 mg/dL) (p<0.001, ANCOVA). In addition to the control for age, the findings were also independent of the levels of triglyceride (TG), total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol. The elevation of RLP-C level in AD and VaD was further distinct in subjects with normotriglyceridemia (p=0.001, ANCOVA). Conclusions: Our results demonstrated that RLP-C is elevated in VaD and AD, and can overcome the limitation of TG with heterogenous atherogenic particles. RLP-C might be a useful marker to indicate the cerebrovascular disease with large vessel problem.

Keywords

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