Hip & pelvis

The Korean Hip Society (대한고관절학회)
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The Tribological and Lubrication Responses of a Cobalt-Chromium Femoral Head in Total Hip Arthroplasty

표면 윤활 물질에 의한 인공 고관절 코발트-크롬 대퇴골두의 마찰 및 윤활 반응

  • Park, Seong-Hun (Institute for Skeletal Aging & Department of Orthopedic Surgery, College of Medicine, Hallym University) ;
  • Truyen, Duong Cong (School of Mechanical Engineering, Pusan National University) ;
  • Lee, Jae-Hoon (School of Mechanical Engineering, Pusan National University) ;
  • Cho, Youn-Ho (School of Mechanical Engineering, Pusan National University) ;
  • Park, Seung-Jae (Institute for Skeletal Aging & Department of Orthopedic Surgery, College of Medicine, Hallym University) ;
  • Park, Keun-Min (Institute for Skeletal Aging & Department of Orthopedic Surgery, College of Medicine, Hallym University) ;
  • Chang, Jun-Dong (Institute for Skeletal Aging & Department of Orthopedic Surgery, College of Medicine, Hallym University) ;
  • Lee, Sang-Soo (Institute for Skeletal Aging & Department of Orthopedic Surgery, College of Medicine, Hallym University)
  • 박성훈 (한림대학교 의과대학 정형외과학교실 골격노화연구소) ;
  • Duong Cong Truyen (부산대학교 기계공학부) ;
  • 이재훈 (부산대학교 기계공학부) ;
  • 조윤호 (부산대학교 기계공학부) ;
  • 박승재 (한림대학교 의과대학 정형외과학교실 골격노화연구소) ;
  • 박근민 (한림대학교 의과대학 정형외과학교실 골격노화연구소) ;
  • 장준동 (한림대학교 의과대학 정형외과학교실 골격노화연구소) ;
  • 이상수 (한림대학교 의과대학 정형외과학교실 골격노화연구소)
  • Published : 2010.09.30
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Abstract

Purpose: This study aimed at investigating the role of albumin as a boundary lubricant in the lubrication of the Co-Cr femoral head of artificial hip implants by measuring the tribological parameters of the Co-Cr femoral head with Atomic Force Microscope (AFM) techniques. Materials and Methods: Samples were prepared from the main wear region of a Co-Cr femoral head from revision hip surgery. Two types of solutions were prepared as lubricants: PBS (Phosphate Buffered Saline) as a control solution and BSA (Bovine Serum Albumin) as a lubricant at concentrations of 10, 20, 30 and 40 mg/ml in PBS solution. Results: There were statistically significant differences in the frictional coefficients (${\mu}$) of a Co-Cr head between the PBS control and all the concentrations of BSA (10, 20, 30, 40 mg/ml) (P<0.001). Similarly, there were statistically significant differences for the ${\mu}$ between the BSA concentrations of 10, 20, 30 and 40 mg/m for all the cases except between the BSA of 30 and 40 mg/ml (P<0.01). Conclusion: There exists a maximum protein concentration of BSA to play a role as an effective boundary lubricant through adsorption on the surface of Co-Cr femoral head.

목적: 인공 고관절에서 알부민의 경계윤활제로서의 영향을 나노 단위 수준에서 확인하기 위하여, 코발트-크롬 대퇴골두를 AFM (Atomic Force Microscope) 을 사용하여 마찰 관련 지표의 변화를 분석하였다. 대상 및 방법: 환자의 코발트-크롬 대퇴골 삽입물의 마모된 부위로부터 실험 모델을 제작하였다. 사용된 윤활제는 대조용액으로 PBS (Phosphate Buffered Saline)가 사용되었으며 실험용액으로는 우혈청 알부민(BSA: Bovine Serum Albumin)가 사용되었다. 결과: 마찰계수 (${\mu}$)는 실험군과 대조군 사이의 마찰계수가 통계적으로 유의하였다(10 mg/ml, 20mg/ml, 30 mg/ml, 40 mg/ml BSA: P<0.001). 각 농도의 BSA 혼합 용액 사이에서도 통계적으로 유의한 마찰계수의 차이를 보였으며, 30 mg/ml와 40 mg/ml사이에서는 마찰계수의 차이가 유의하지 않았다. 결론: 코발트-크롬 대퇴골두의 표면에 흡착되어서 경계 윤활 작용의 효과를 극대화 시킬 수 있는 효과적인 단백질 농도가 존재한다.

Keywords

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