Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Development of BioEquiv, a Computer Program for the Analysis of Bioequivalence

생물학적동등성시험을 위한 통계처리 프로그램(BioEquiv)의 개발

  • Yoon, Sang-Hoo (Department of Statistics, Chonnam National University) ;
  • Hwang, Nan-A (Team of University-Industry Cooperation Program, National Research Foundation of Korea) ;
  • Lim, Young-Chai (Department of Pharmacology, Chonnam National University Medical School) ;
  • Lee, Yong-Bok (College of Pharmacy, Chonnam National University) ;
  • Park, Jeong-Soo (Department of Statistics, Chonnam National University)
  • 윤상후 (전남대학교 통계학과) ;
  • 황난아 (한국연구재단 산학협력지원단) ;
  • 임영채 (전남대학교 의과대학 약리학교실) ;
  • 이용복 (전남대학교 약학대학) ;
  • 박정수 (전남대학교 통계학과)
  • Published : 2010.02.20
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Abstract

K-$BEtest^{(R)}$ is a well known program for bioequivalence test using a $2{\times}2$ design. Lee et al.(1998) and Park et al.(1999) suggested a $3{\times}3$ and $3{\times}2$ design, and also discussed their benefits. We developed a computer program, called BioEquiv, which can analyze some complex experimental designs such as, $3{\times}3$ design and $3{\times}2$ design including a standard $2{\times}2$ design. This program is a user-friendly one and overcomes the disadvantages of K-$BEtest^{(R)}$. The detailed statistical formula and structure of BioEquiv are presented with some examples. The comparison between K-$BEtest^{(R)}$ and BioEquiv are given with actual data analysis. BioEquiv is able to present a table of ANOVA test over some complex experimental designs. Moreover K-$BEtest^{(R)}$ and BioEquiv draw the same result when data consists of $2{\times}2$ design.

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References

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