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Synthesis and Studies on Anticonvulsant and Antidepressant Activities of 5-Alkoxy-tetrazolo[1,5-a]quinolines

  • Deng, Xian-Qing (College of Pharmacy, Yanbian University) ;
  • Wei, Cheng-Xi (Institute of Neurosurgery, Inner Mongolia University for Nationalities) ;
  • Song, Ming-Xia (College of Pharmacy, Yanbian University) ;
  • Chai, Kyu-Yun (Department of chemistry, Wonkwang University) ;
  • Sun, Zhi-Gang (Institute of Neurosurgery, Inner Mongolia University for Nationalities) ;
  • Quan, Zhe-Shan (College of Pharmacy, Yanbian University)
  • Published : 2010.02.20

Abstract

A series of 5-alkoxy-tetrazolo[1,5-a]quinolines were synthesized to evaluate their anticonvulsant and antidepressant effects. Anticonvulsant effects and neurotoxicity of the compounds when injected intraperitoneally to mice were determined by a maximal electroshock (MES) test and a rotarod test, respectively. Only three of the synthesized compounds (4a, 4b, 4c) displayed anticonvulsant activity at a dose of 300 mg/kg. Most of the compounds significantly reduced immobility times during the forced swimming test (FST) at a dose of 100 mg/kg, indicative of antidepressant activity. Among the compounds, 5-(2-fluorobenzyloxy)tetrazolo[1,5-a]quinoline (4k) reduced immobility time by 66.85% at 30 mg/kg compared with the same dose of Fluoxetine, which reduced immobility time by 52.30%. According to the results of the 5-Hydroxytryptophan induced head-twitch test and yohimbine toxicity potentiation test, the noradrenergic system seems not to be involved in the antidepressant-like effect of compound 4k while the serotonergic system seems a little to be involved.

Keywords

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