생명과학회지 (Journal of Life Science)

  • 제20권12호
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  • Pages.1838-1843
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  • 2010
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  • 1225-9918(pISSN)
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  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
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양조 부산물인 주박의 주름개선 효과

Anti-Wrinkle Effects of Korean Rice Wine Cake on Human Fibroblast

  • Yoo, Jung-Min (Division of Biological Science and Technology, College of Science and Technology, Yonsei University) ;
  • Kang, Yeo-Jin (Division of Biological Science and Technology, College of Science and Technology, Yonsei University) ;
  • Pyo, Hyeong-Bae (R&D Center, Hanbul Cosmetics Co.) ;
  • Choung, Eui-Su (R&D Center, DANJOUNGBIO Ltd. Co.) ;
  • Park, Shin-Young (Rural Development Administiration, Fermention & Food Processing Division) ;
  • Choi, Ji-Ho (Rural Development Administiration, Fermention & Food Processing Division) ;
  • Han, Gwi-Jung (Rural Development Administiration, Fermention & Food Processing Division) ;
  • Lee, Choong-Hwan (Department of Bioscience and Biotechnology and Bio/Molecular Informatics Center, Konkuk University) ;
  • Kim, Tack-Joong (Division of Biological Science and Technology, College of Science and Technology, Yonsei University)
  • 투고 : 2010.08.31
  • 심사 : 2010.10.26
  • 발행 : 2010.12.30
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초록

피부의 노화는 유전자 돌연변이와 같은 유전적인 요소와 자외선 노출과 같은 환경적인 요소와 연관되어 있다. 이러한 요소들은 교원질과 탄력섬유와 같은 피부의 구조적인 복합체를 분해한다. 특히, 교원질은 전사인자인 AP-1에 의해 유도되는 분해효소인 MMP-1에 의해 분해되고 그 결과 피부의 주름이 발생한다. 교원질의 다른 분해 원인으로는 생체내 활성산소의 생성을 들 수 있다. 활성산소의 생성은 세포막을 공격하고 MMP-1의 활성을 유도한다. 결과적으로, 피부 탄력의 감소와 동시에 피부의 노화를 촉진시키게 된다. 본 연구에서 우리는 양조 부산물인 주박을 이용하여 항산화효과, collagen 합성촉진효과, MMP-1의 발현양상을 측정하였다. 흥미롭게도, 주박은 DPPH 라디컬의 소거활성 효과와 procollagen의 양을 증가시킴과 동시에, MMP-1의 유전자 발현을 억제시키는 효과를 나타내었다. 본 결과는 주박이 피부의 항노화 효과를 가질 수 있다는 것을 제시한다.

Skin aging is related to genetic and environmental factors (e.g., gene mutation and UV radiation respectively). To develop a new anti-wrinkle cosmetic or functional food by using Korean rice wine cake, we examined the effects of Korean rice wine cake, a brewery byproduct, on antioxidant effect, collagen synthesis and expression of MMP-1. Interestingly, we found that Korean rice wine cake has the ability to promote scavenging activity of DPPH radical. We also found that the cell proliferation and synthesis of collagen in HS27 cells was increased by Korean rice wine cake in a concentration-dependent manner. However, elastase inhibitory activity was not changed. In addition, the expression of MMP-1 was inhibited by Korean rice wine cake in a concentration-dependent manner. All these results suggest that Korean rice wine cake can be effectively used for the prevention of wrinkles in human skin.

키워드

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