The Hepatoprotective Activity of Spatholobi Caulis Water Extract against Cadmium-Induced Toxicity in Rats

계혈등 물추출물의 간세포 보호효과

  • Park, Won-Mook (Department of Oriental Internal Medicine, Daegu Haany University) ;
  • Choi, Hong-Sik (Department of Oriental Internal Medicine, Daegu Haany University) ;
  • Kim, Seung-Mo (Department of Oriental Internal Medicine, Daegu Haany University) ;
  • Woo, Chang-Hoon (Department of Oriental Rehabilitation Medicine, Daegu Haany University)
  • 박원묵 (대구한의대학교 한의학과 간계내과학교실) ;
  • 최홍식 (대구한의대학교 한의학과 간계내과학교실) ;
  • 김승모 (대구한의대학교 한의학과 간계내과학교실) ;
  • 우창훈 (대구한의대학교 한의학과 한방재활의학과교실)
  • Received : 2010.06.21
  • Accepted : 2010.09.09
  • Published : 2010.09.30

Abstract

Objectives: This study was investigated the protective effect of Spatholobi Caulis water extract against cadmium (CdCl2, Cd)-induced hepatic toxicity in rats. Methods: To induce acute hepatic toxicity, Cd (4 mg/kg body weight) was dissolved in normal saline and intravenously injected into rats. Then, the rats received either a vehicle or silymarin (100 mg/kg) or Spatholobi Caulis water extract (30, 50 mg/kg/day) for 3 days, and were exposed to a single injection of Cd 24 h after the last Spatholobi Caulis/vehicle treatment. Results: Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were significantly increased by Cd treatment. In contrast, pretreatment with Spatholobi Caulis reduced ALT, AST and LDH. Cd-intoxicated liver damage was significantly inhibited by treatment of Spatholobi Caulis 30 and 50 mg/kg at histopathological observations in the present study. Conclusions: These results can be considered as direct evidence that Spatholobi Caulis has favorable inhibitory effects on the Cd-intoxicated liver damages. The efficacy of Spatholobi Caulis 30 mg/kg shows similar effects to that of silymarin 100 mg/kg, and more favorable hepatoprotective effects were observed in Spatholobi Caulis 50 mg/kg as compared with silymarin 100 mg/kg against Cd-intoxicated hepatopathies in the present study.

Keywords

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