Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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DNA Vaccines against Infectious Diseases and Cancer

  • Han, Duk-Jae (Department of Microbiology, School of Medicine, Catholic University of Daegu) ;
  • Weiner, David B. (Department of Pathology and Laboratory Medicine, University of Pennsylvania) ;
  • Sin, Jeong-Im (Department of Microbiology, School of Medicine, Catholic University of Daegu)
  • Published : 2010.01.31
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Abstract

Progress in the development of DNA vaccines and their delivery strategies has been made since their initial concept as a next generation vaccine. Since DNA vaccine includes non-infectious DNA parts of pathogens, it can't cause disease yet it closely mimic the natural process of infection and immune responses. Despite their early promising results of controlling infectious diseases and cancer in small animal models, DNA vaccines failed to display a level of immunogenicity required for combating these diseases in humans, possibly due to their lower protein expression levels. However, increasing evidence has shown that DNA vaccines are clinically well-tolerated and safe. Furthermore, one notable advantage of DNA vaccines includes convenient utilities of plasmid DNAs coding for antigens. For instance, any emerging pathogens could be prevented easily and timely by allowing the simple exchange of antigen-encoding genes. In this review, newly developed DNA vaccine strategies, including electroporation, which has emerged as a potent method for DNA delivery, targeting infectious diseases and cancer will be discussed with a focus on any on-going DNA vaccine trials or progress made pre-clinically and in clinics.

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References

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