Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Quinolone Alkaloids from Evodiae fructus Inhibit LFA-1/ICAM-1-mediated Cell Adhesion

  • Lee, Seung-Woong (Korea Research Institute of Bioscience and Biotechnology) ;
  • Chang, Jong-Sun (Korea Research Institute of Bioscience and Biotechnology) ;
  • Lim, Ju-Hwan (Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Min-Seok (Korea Research Institute of Bioscience and Biotechnology) ;
  • Park, Su-Jin (Korea Research Institute of Bioscience and Biotechnology) ;
  • Jeong, Hyung-Jae (Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Min-Soo (Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Woo-Song (Korea Research Institute of Bioscience and Biotechnology) ;
  • Rho, Mun-Chual (Korea Research Institute of Bioscience and Biotechnology)
  • Published : 2010.01.20
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Abstract

Four quinolone alkaloids were isolated by bioactivity-guided fractionation from the methanol extracts of Evodiae fructus fruits. Structures of compounds were elucidated by spectroscopic analysis ($^1H$-, $^{13}$C-NMR and MS), as follows: 1-methyl-2-undecyl-4(1H)-quinolone (1), evocarpine (2), dihydroevocarpine (3) and mixture of [1-methyl-2-[(Z)-10-pentadecenyl]-4(1H)-quinolone and 1-methyl-2-[(Z)-6-pentadecenyl]-4(1H)-quinolone] (4). They inhibited the interaction of sICAM-1 and LFA-1 in THP-1 cells at $IC_{50}$ values of >150 (1), 109.8 (2), >150 (3) and $40.9 {\mu}M$ (4), respectively,

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