대한임상검사과학회지 (Korean Journal of Clinical Laboratory Science)
- 제42권3호
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- Pages.136-148
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- 2010
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- 1738-3544(pISSN)
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- 2288-1662(eISSN)
아연 전처리가 시간 경과에 따른 카드뮴 유도 고환 독성에 미치는 보호 효과
Preventive Effects of Zinc Pretreatment in the Time-course of Cadmium-induced Testicular Toxicity in the Rat
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Jekal, Seung-Joo
(Department of Clinical Laboratory Science, Wonkwang Health Science University) ;
- Lee, Kyung-Sun (Department of Clinical Laboratory Science, Wonkwang Health Science University) ;
- Chung, Ok-Bong (Department of Clinical Pathology, Jeonju Kijeon College) ;
- Im, Hyo-Bin (Department of Diagnostic Laboratory Medicine, Wonkwang University Hospital)
- 투고 : 2010.09.26
- 심사 : 2010.12.23
- 발행 : 2010.12.30
초록
Cadmium (Cd) is known to exert gonadotoxic and spermiotoxic effects. The present study was performed to investigate the morphological effects and metallothionein (MT) expression by zinc pretreatment in the course of time of cadmium-induced testicular injury in rat. Fifty male Spraque-Dawley rats weighing 160-180 g were divided into two groups: saline-pretreated cadmium group and zinc-pretreated cadmium group. Rats of two groups received subcutaneous injection of saline and 100 mg/kg