Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)
- Volume 42 Issue 2
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- Pages.63-70
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- 2010
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- 1738-3544(pISSN)
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- 2288-1662(eISSN)
The Frequency and Distribution of Unexpected Antibodies at a Tertiary Hospital in Daejeon
대전지역 대학병원에서 동정된 비예기항체의 분포와 빈도
- Kang, Hee-Jung (Department of Biomedical Laboratory Science, School of Medicine, Eulji University) ;
- Ihm, Chun-Hwa (Department of Biomedical Laboratory Science, School of Medicine, Eulji University) ;
- Lee, Moon-Hee (Department of Laboratory Medicine, Eulji University Hospital) ;
- Hyun, Sung-Hee (Department of Biomedical Laboratory Science, School of Medicine, Eulji University) ;
- Kim, In-Sik (Department of Biomedical Laboratory Science, School of Medicine, Eulji University)
- 강희정 (을지대학교 의과대학 임상병리학과) ;
- 임춘화 (을지대학교 의과대학 임상병리학과) ;
- 이문희 (을지대학병원 진단검사의학과) ;
- 현성희 (을지대학교 의과대학 임상병리학과) ;
- 김인식 (을지대학교 의과대학 임상병리학과)
- Received : 2010.05.17
- Accepted : 2010.12.10
- Published : 2010.08.30
Abstract
Antibody screening and identification tests before blood transfusion are important because unexpected red antibodies can cause acute or delayed hemolytic transfusion reactions. Although a tube method was used for detecting unexpected antibodies, a column agglutination method has recently been used because of its simple procedure and a high detection of warm antibodies. This study investigated the frequency and distribution of unexpected antibodies in transfusion candidates during the recent 5 years, and transfusion characteristics in the identified cases. From January 2005 to December 2009, 46,923 sera of the cases from E hospital were screened and 98 sera were identified by the DiaMed-ID System. 272 cases (0.58%) showed positive results out of all 46,923 cases that underwent unexpected antibodies screening. Among them, unexpected antibodies were identified in 98 cases. The anti-Rh antibodies included in warm antibodies were the most frequently detected in 47 cases (47.96%). Anti-Lewis and anti-MNSs antibodies were detected in 11 cases (11.22%) and 6 cases (6.12%), respectively. Unidentified antibodies were detected in 6 cases (6.12%). Among the patients with unexpected antibodies, 43 cases (43.88%) had a history of previous transfusion. Anti-E was the most frequently detected antibody (4/14 cases, 30.77%) in the cases who had a previous history of transfusion and showed different screening results from negative to positive, This study may provide the basic data for the frequency and characteristics of red cell antibodies.
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