Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
권호 표지

Surgical Treatment for Granulosa Cell Tumor in a Thoroughbred Mare

말에서 Granulosa Cell Tumor에 의한 무발정 치료 예

  • Seo, Jong-Pil (Department of Veterinary Surgery and BK21 Program for Veterinary Science, Seoul National University) ;
  • Son, Won-Gyun (Department of Veterinary Surgery and BK21 Program for Veterinary Science, Seoul National University) ;
  • Gang, Su-Jin (Department of Veterinary Surgery and BK21 Program for Veterinary Science, Seoul National University) ;
  • Kim, Hyung-Jin (Veterinary Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Kim, Dae-Yong (Veterinary Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Lee, Choung-Seop (Surabol Equine Veterinary Clinic) ;
  • Lee, In-Hyung (Department of Veterinary Surgery and BK21 Program for Veterinary Science, Seoul National University)
  • 서종필 (서울대학교 수의과대학 수의외과학교실.BK21) ;
  • 손원균 (서울대학교 수의과대학 수의외과학교실.BK21) ;
  • 강수진 (서울대학교 수의과대학 수의외과학교실.BK21) ;
  • 김형진 (서울대학교 수의과대학 병리학교실) ;
  • 김대용 (서울대학교 수의과대학 병리학교실) ;
  • 이충섭 (서라벌 동물병원) ;
  • 이인형 (서울대학교 수의과대학 수의외과학교실.BK21)
  • Published : 2009.10.31
Download PDF
⟨ Previous Next ⟩

Abstract

An 8-year-old Thoroughbred mare showing anestrus for longer than 6 months with left ovarian mass was referred to Veterinary Medical Teaching Hospital of Seoul National University. For 6 months, the mare had received 2 times hormonal therapies with $PGF_2{\alpha}$ and progesterone. The mare had not responded to these therapies and not shown estrous behavior. On rectal palpation, the left ovary was enlarged and contralateral ovary was small and inactive. Transrectal ultrasonographic examination of the left ovary revealed a mass composed of multiple, irregularly shaped follicles. Granulosa cell tumor (GCT) was suspected according to her history. Ovariectomy was performed through the left flank laparotomy with a standing position in a simple chute located outside of horse farm. The mass was diagnosed as GCT on histopathology. The mare was recovered without any problem and became pregnant next spring.

Keywords

References

  1. Bailey MT, Troedsson MH, Wheato JE. Inhibin concentrations in mares with granulosa cell tumors. Theriogenology 2002; 57: 1885-1895 https://doi.org/10.1016/S0093-691X(02)00658-1
  2. Bosu WT, Van Camp SC, Miller RB, Owen RR. Ovarian disorders: clinical and morphological observations in 30 mares. Can Vet J 1982; 23: 6-14
  3. Embertson RM. Ovaries and uterus. In: Equine surgery, 3rd ed. St. Louis: Saunders. 2006: 855-864
  4. England GCW. Non-infectious infertility in mares. In: Fertility and obstetrics in the horse, 3rd ed. Ames: Blackwell. 2005: 103-115
  5. Frederico LM, Gerard MP, Pinto CR, Gradil CM. Bilateral occurrence of granulosa-theca cell tumors in an Arabian mare. Can Vet J 2007; 48: 502-505
  6. Held JP, Blackford J. Surgical correction of abnormalities of the female reproductive organs. In: Current therapy in large animal theriogenology, 2nd ed. St. Louis: Saunders. 2007: 198-210
  7. Hinrichs K. Irregularities of the estrous cycle and ovulation in mares (including seasonal transition). In: Current therapy in large animal theriogenology, 2nd ed. St. Louis: Saunders. 2007: 144-152
  8. Hoque S, Derar RI, Osawa T, Taya K, Watanabe G, Miyake Y. Spontaneous repair of the atrophic contralateral ovary without ovariectomy in the case of a granulosa theca cell tumor (GTCT) affected mare. J Vet Med Sci 2003; 65: 749-751 https://doi.org/10.1292/jvms.65.749
  9. Hoque S, Senba H, Tsunoda N, Derar RI, Watanabe G, Taya K, Osawa T, Miyake Y. Endocrinological changes before and after removal of the granulosa theca cell tumor (GTCT) affected ovary in 6 mares. J Vet Med Sci 2003; 65: 887-891 https://doi.org/10.1292/jvms.65.887
  10. MacLachlan NJ. Ovarian disorders in domestic animals. Environ Health Perspect 1987; 73: 27-33 https://doi.org/10.2307/3430595
  11. McCue PM. Neoplasia of the female reproductive tract. Vet Clin North Am Equine Pract 1998; 14: 505-515
  12. McCue PM, LeBlanc MM, Akita GY, Pascoe JR, Witherspoon DM, Stabenfeldt GH. Granulosa cell tumors in two cycling mares. J Equine Vet Sci 1991; 11: 281-282 https://doi.org/10.1016/S0737-0806(06)81316-X
  13. Patrick DJ, Kiupel M, Gerber V, Carr EA. Malignant granulosa- theca cell tumor in a two-year-old Miniature horse. J Vet Diagn Invest 2003; 15: 60-63
  14. Pinto CRF, Paccamonti DL. Mare reproductive pathology. In: Equine internal medicine, 2nd ed. St. Louis: Saunders. 2004: 1039-1049
  15. Rodgerson DH, Brown MP, Watt BC, Keoughan CG, Hanrath M. Hand-assisted laparoscopic technique for removal of ovarian tumors in standing mares. J Am Vet Med Assoc 2002; 220: 1503-1507 https://doi.org/10.2460/javma.2002.220.1503
  16. Sundberg JP, Burnstein T, Page EH, Kirkham WW, Robinson FR. Neoplasms of equidae. J Am Vet Med Assoc 1977; 170: 150-152