Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Association Analysis of Polymorphisms on Dystrobrevin Binding Protein 1(DTNBP1) Gene with Schizophrenia in the Korean Population

한국인에서 Dystrobrevin Binding Protein 1(DTNBP1) 유전자의 다형성과 정신분열병의 연합에 대한 고찰

  • Moon, Hyun-Il (Department of Neuropsychiatry, College of Medicine Soonchunhyang University, Soonchunhyang University Hospital) ;
  • Lee, Yeon Jung (Department of Neuropsychiatry, College of Medicine Soonchunhyang University, Soonchunhyang University Hospital) ;
  • Park, Byung-Lae (SNP Genetics) ;
  • Shin, Hyung Doo (SNP Genetics) ;
  • Choi, Ihn-Geun (Department of Neuropsychiatry, Hallym University College of Medicine, Hangang Sacred Heart Hospital) ;
  • Han, Sun Ho (Department of Neuropsychiatry, College of Medicine Soonchunhyang University, Soonchunhyang University Hospital) ;
  • Woo, Sung-Il (Department of Neuropsychiatry, College of Medicine Soonchunhyang University, Soonchunhyang University Hospital)
  • 문현일 (순천향대학교 의과대학 순천향대학교병원 신경정신과학교실) ;
  • 이연정 (순천향대학교 의과대학 순천향대학교병원 신경정신과학교실) ;
  • 박병래 ((주) 에스엔피 제네틱스) ;
  • 신형두 ((주) 에스엔피 제네틱스) ;
  • 최인근 (한림대학교 의과대학 한강성심병원 신경정신과학교실) ;
  • 한선호 (순천향대학교 의과대학 순천향대학교병원 신경정신과학교실) ;
  • 우성일 (순천향대학교 의과대학 순천향대학교병원 신경정신과학교실)
  • Published : 2009.08.31
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Abstract

Objectives : This study was designed to investigate the association of schizophrenia and P1320, P1325, P1635, P1655, P1763 and SNP A polymorphisms on dystrobrevin binding protein 1(DTNBP1) gene in Korean patients. Methods : We analyzed P1320, P1325, P1635, P1655, P1763 and SNP A polymorphisms on DTNBP1 gene from their DNAs extracted from their blood in 388 Korean schizophrenic patients (male 198, female 190) and 372 control subjects(male 247, female 125). We compared the differences of genotype and allele distributions of the six polymorphisms on DTNBP1 gene between the Korean schizophrenic patient group and the normal control group. Results : There were no statistically significant differences of genotype and allele distributions of the P1320, P1325, P1635, P1655, P1763 and SNP A polymorphisms on DTNBP1 gene between the schizophrenic patient group and the normal control group. Conclusion : The results of this study suggest that P1320, P1325, P1635, P1655, P1763 and SNP A polymorphism on DTNBP1 gene do not have influence on the risk of the schizophnenic in the Korean population.

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