Journal of the Korea Academia-Industrial cooperation Society (한국산학기술학회논문지)

The Korea Academia-Industrial cooperation Society (한국산학기술학회)
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Evaluation of Epidemic Characteristics of Extended Spectrum β-Lactamase Producing Bacteria Isolated from Blood Cultures

혈액배양에서 분리된 Extended Spectrum β-Lactamase 생성균의 역학적 특성 조사

  • Seo, Choong-Won (Department of Laboratory Medicine Konyang University Hospital) ;
  • Kim, Sang-Ha (Department of Public Health and Welfare Graduate school of Konyang University) ;
  • Hwang, Seock-Yeon (Department of Biomedical Laboratory Science, Daejeon University) ;
  • Kim, Young-Kwon (Department of Biomedical Laboratory Science Konyang University)
  • 서충원 (건양대학교병원 진단검사의학과) ;
  • 김상하 (건양대학교 보건대학원) ;
  • 황석연 (대전대학교 임상병리학과) ;
  • 김영권 (건양대학교 임상병리학과)
  • Published : 2009.09.30
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Abstract

The data which analyze the results of blood cultures are crucial basic information of the empirical therapy for patients with infection since the patterns of the species of microorganism isolated from blood and the results of antibiotic susceptibility test vary depending upon patients general features. Especially, in case of ESBL-producing bacteria, there is a close relation with use of antibiotics. Therefore, we carried out the research with the results of blood culture and antibiotic. 1. Total 39,305 cases of blood culture samples were investigated and positive patients of 2,216 (20.0%) were found. Among those, there were 40 patients with ESBL positive, and blood culture positive samples were 4,798 (12.2%). ESBL positive bacteria were found in 86 samples (including double checked culture bacteria). 2. The majority of ESBL producing bacteria were E. coli, K. pneumoniae and K. oxitoca as ordering based on the number. 3. The research showed the results that there were more females than male with the bacterias, more E. coli in over 50 years old aged group than other bacterias, more K. pneumoniae and K.oxitoca in less 1 year old aged group than other bacterias and largest numbers of patients with 13 patients (32.5%) in Chungcheongnam-do province were found. 4. The most common ESBL producing bacteria were E. coli throughout 3 years, but K, pneumoniae and K. oxitoca were also fairly found. Interestingly, E. coli was highly found in over 50 years old patients.

본 연구는 혈액에서 분리되는 미생물의 균종과 항균제 감수성 검사 결과 양상은 환자의 일반적 특성에 따라 다르므로 혈액배양 결과를 분석한 자료는 감염증 환자의 경험적 치료를 위한 중요한 근거가 되고, 특히 ESBL을 생성하는 균주의 경우 항균제의 사용과도 밀접한 관련이 있어 이 연구를 하게 되었다. 혈액배양 결과와 항균제 내성 결과를 분석한 결과는 다음과 같다. 1. 39.305건의 혈액배양이 의뢰되어 양성 환자 수는 2,216명(20.0%)이었고, 이중에서 ESBL양성 환자 수는 40명 이었으며, 혈액배양 양성은 4,798건(12.2%)이었으며 ESBL양성 균주는 86건(중복 배양 균주 포함)이었다. 2. ESBL을 생성하는 세균 중에서 분리된 균종은 E. coli, K. pneumoniae, K. oxitoca의 순 이었다. 3. 성별로는 여자가 다소 많았고, 연령별로는 50세 이상의 군에서 E. coli, 1세 미만의 군에서는 K. pneumoniae, K. oxitoca 의 분리가 많았고, 지역별로는 충청남도 13명(32.5%)로 가장 많았다. 4. 3년간 일개대학병원의 혈액배양에서 ESBL양성인 균종 중 가장 흔히 분리되는 것은 E. coli이고, K. pneumoniae, K. oxitoca 등이 다음으로 분리 되었고, 50세 이상의 환자에서 E. coli의 분리 비율이 높았다.

Keywords

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