Journal of the East Asian Society of Dietary Life (동아시아식생활학회지)

The East Asian Society of Dietary Life (동아시아식생활학회)
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A Study on the Relationship of Serum Vitamin D Levels with Insulin Resistance in Premenopausal Women

폐경 전 여성에서 혈청 비타민 D 농도와 인슐린 저항성에 관한 연구

  • Lee, Ji-Hye (Dept. of Internal Medicine, Eulji University School of Medicine) ;
  • Hong, Jun-Hwa (Dept. of Internal Medicine, Eulji University School of Medicine) ;
  • Kim, Hyun-Jin (Dept. of Internal Medicine, Eulji University School of Medicine) ;
  • Park, Kang-Seo (Dept. of Internal Medicine, Eulji University School of Medicine) ;
  • Lee, Jae-Min (Korea Association of Health Promotion) ;
  • Kim, Byung-Joon (Dept. of Internal Medicine, School of Medicine, Konyang University) ;
  • Ahn, Kyu-Jeung (Dept. of Internal Medicine, Kyung Hee University School of Medicine) ;
  • Jeong, Bi-O (Dept. of Orthopedic Surgery, Kyung Hee University School of Medicine) ;
  • Kim, Sung-Hwan (Dept. of Food and Nutrition, Joongbu University) ;
  • Lee, Seong-Kyu (Dept. of Internal Medicine, Eulji University School of Medicine)
  • 이지혜 (을지대학교 의과대학 내과학교실) ;
  • 홍준화 (을지대학교 의과대학 내과학교실) ;
  • 김현진 (을지대학교 의과대학 내과학교실) ;
  • 박강서 (을지대학교 의과대학 내과학교실) ;
  • 이재민 (한국건강관리협회) ;
  • 김병준 (건양대학교 의과대학 내과학교실) ;
  • 안규정 (경희대학교 의과대학 내과학교실) ;
  • 정비오 (경희대학교 의과대학 정형외과학교실) ;
  • 김성환 (중부대학교 식품영양학과) ;
  • 이성규 (을지대학교 의과대학 내과학교실)
  • Received : 2009.08.28
  • Accepted : 2009.09.16
  • Published : 2009.10.31
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Abstract

Vitamin D levels have been reported to be associated with diabetes, obesity and metabolic syndrome. There have been studies on the nutritional status of vitamin D in postmenopausal women at Seoul and premenopausal women at Busan, and these studies showed that nearly no relationship between serum vitamin D levels and the obesity index existed. However, there have been no studies that examined about the relationship between serum vitamin D levels and insulin resistance in Korea. In this study, we investigated serum vitamin D levels and the relationship between serum vitamin D levels and insulin resistance (homeostasis model assessment of insulin resistance), obesity index (body mass index, percentage of body fat and waist circumference) in 180 premenopausal women (non-obese women 87.8%, obese women 12.2%) in spring (March~April), fall (September~October) and winter (January~February) at Daejeon. Serum vitamin D levels were lower in winter than in spring-fall, after adjusting for age and the obesity index. The frequency of vitamin D inadequacy (serum vitamin D levels were $\leq$ 20 ng/mL) was 45.5% in winter and, 23.5% in spring-fall, and which showed that vitamin D inadequacy was higher in winter than in spring-fall. Multiple regression analysis showed that serum vitamin D levels had no relationship with the obesity index or insulin resistance. There was no difference in the obesity index or insulin resistance between the vitamin D inadequacy and normal group, and there was no relationship between serum vitamin D levels and the obesity index or insulin resistance in non-obese and obese premenopausal women, respectively. In conclusion, serum vitamin D levels in premenopausal women at Daejeon were lower in winter than in spring-fall, and the frequency of vitamin D inadequacy was higher in winter than in spring-fall. Serum vitamin D levels had no relationship with the obesity index or insulin resistance in premenopausal women, most of whom were not obese.

Keywords

References

  1. Arunabh S, Pollack S, Yeh J, Aloia JF (2003) Body fat content and 25-hydroxyvitamin D levels in healthy women. J Clin Endocrinol Metab 88: 157-161. https://doi.org/10.1210/jc.2002-020978
  2. Barger-Lux MJ, Heaney RP (2002) Effects of above average summer sun exposure on serum 25-hydroxyvitamin D and calcium absorption. J Clin Endocrinol Metab 87: 4952-4956. https://doi.org/10.1210/jc.2002-020636
  3. Chang WC, Kwon IS, Park BJ, Bae SH, Park SC (2003) The association of vitamin D and parathyroid hormone with bone mineral density in Korean postmenopausal women. J Korean Geriatr Soc 7: 194-205.
  4. Chapuy MC, Preziosi P, Maamer M, Arnaud S, Galan P, Hercberg S, Meunier PJ (1997) Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos Int 7: 439-443. https://doi.org/10.1007/s001980050030
  5. Chen SH, Jen IA, Chuang SY, Lin KC, Chou P (2006) Community-based study on summer-winter differences of component of metabolic syndrome in Kinmen, Taiwan. Prev Med 43: 129-135. https://doi.org/10.1016/j.ypmed.2006.02.013
  6. Ford ES, Ajani UA, McGuire LC, Liu S (2005) Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults. Diabetes Care 28: 1228-1230. https://doi.org/10.2337/diacare.28.5.1228
  7. Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18: 499-502.
  8. Haffner SM, Miettinen H, Stern MP (1997) The homeostasis model in the San Antonio Heart Study. Diabetes Care 20: 1087-1092. https://doi.org/10.2337/diacare.20.7.1087
  9. Holick MF (2002) Vitamin D: The underappreciated D-lightful hormone that is important for skeletal and cellular health. Curr Opin Endocrinol Diabetes 9: 87-98. https://doi.org/10.1097/00060793-200202000-00011
  10. Hollis BW, Pittard WB 3rd. (1984) Evaluation of the total fetomaternal vitamin D relationships at term: evidence for racial differences. J Clin Endocrinol Metab 59: 652-657. https://doi.org/10.1210/jcem-59-4-652
  11. Jarrett RJ, Murrells TJ, Shipley MJ, Hall T (1984) Screening blood glucose values: Effects of season and time of day. Diabetologia 27: 574-577. https://doi.org/10.1007/BF00276970
  12. Kim GS, Kim SY, Kim MK, Lim DJ, Lee SS, Baek KH, Han JH, Song KH, Kim HS, Lee KW, Son HY, Kang MI (2008) Reappraisal of the prevalence of vitamin D inadequacy in Korea: A single center's experience. Korean J Bone Metabolism 15: 109-115.
  13. Lee ES, Park HM (2006) The relationship between serum vitamin D concentration and body mass index in Korean postmenopausal women. J Korean Soc Menopause 12: 141-147.
  14. Lemire JM (1995) Immunomodulatory actions of 1,25-dihydroxyvitamin $D_3$. J Steroid Biochem Mol Biol 53: 599-602. https://doi.org/10.1016/0960-0760(95)00106-A
  15. Lim HJ (2005) Serum 25-hydroxyvitamin D status and associated factors in premenopausal working women. Korean J Community Nutr 10: 79-90.
  16. Lim HJ, Kim JI (2006) Serum 25-hydroxyvitamin D status in wintertime in premenopausal working women. Korean J Nutr 39: 649-660.
  17. Lips P (2006) Vitamin D physiology. Prog Biophys Mol Biol 92: 4-8. https://doi.org/10.1016/j.pbiomolbio.2006.02.016
  18. Looker AC (2005) Body fat and vitamin D status in black versus white women. J Clin Endocrinol Metab 90: 635-640. https://doi.org/10.1210/jc.2004-1765
  19. Malabanan A, Veronikis IE, Holick MF (1998) Redefining vitamin D insufficiency. Lancet 351: 805-806.
  20. Martins D, Wolf M, Pan D, Zadshir A, Tareen N, Thadhani R, Felsenfeld A, Levine B, Mehrotra R, Norris K (2007) Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med 167: 1159-1165. https://doi.org/10.1001/archinte.167.11.1159
  21. O''Brien KO, Nathanson MS, Mancini J, Witter FR (2003) Calcium absorption is significantly higher in adolescents during pregnancy than in the early postpartum period. Am J Clin Nutr 78: 1188-1193. https://doi.org/10.1093/ajcn/78.6.1188
  22. Parikh SJ, Edelman M, Uwaifo GI, Freedman RJ, Semega Janneh M, Reynolds J, Yanovski JA (2004) The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab 89: 1196-1199. https://doi.org/10.1210/jc.2003-031398
  23. Park HM, Kim JG, Choi WH, Lim SK, Kim GS (2003) The vitamin D nutritional status of postmenopausal women in Korea. Korean J Bone Metabolism 10: 47-55.
  24. Pittas AG, Lau J, Hu FB, Dawson-Hughes B (2007) The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 92: 2017-2029. https://doi.org/10.1210/jc.2007-0298
  25. Scragg R, Sowers M, Bell C (2004) Third national health and nutrition examination survey: Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the third national health and nutrition examination survey. Diabetes Care 27: 2813-2818. https://doi.org/10.2337/diacare.27.12.2813
  26. Seth A, Marwaha RK, Singla B, Aneja S, Mehrotra P, Sastry A, Khurana ML, Mani K, Sharma B, Tandon N (2009) Vitamin D nutritional status of exclusively breast fed infants and their mothers. J Pediatr Endocrinol Metab 22: 241-246.
  27. Shin JS, Song CH, Cho DJ, Lee BS, Bai SW, Park JH, Park KH (2005) The effects of vitamin D and parathyroid hormone in Korean postmenopausal women. J Korean Soc Menopause 11: 56-62.
  28. Snijder MB, van Dam RM, Visser M, Deeg DJ, Dekker JM, Bouter LM, Seidell JC, Lips P (2005) Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. J Clin Endocrinol Metab 90: 4119-4123. https://doi.org/10.1210/jc.2005-0216
  29. Suarez L, Barrett-Connor E (1982) Seasonal variation in fasting plasma glucose levels in man. Diabetologia 22: 250-253. https://doi.org/10.1007/BF00281300
  30. van der Wielen RP, Lowik MR, van den Berg H, de Groot LC, Haller J, Moreiras O, van Staveren WA (1995) Serum vitamin D concentrations among elderly people in Europe. Lancet 346: 207-210. https://doi.org/10.1016/S0140-6736(95)91266-5
  31. Walters MR (1992) Newly identified actions of the vitamin D endocrine system. Endocr Rev 13: 719-764.