Journal of the Korean Academy of Child and Adolescent Psychiatry

대한소아청소년정신의학회 (Korean Academy of Child and Adolescent Psychiatry)
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자폐 장애에서의 국소 대뇌관류 이상

Regional Cerebral Perfusion Abnormalities in Autistic Disorder : Statistical Parametric Mapping Analysis

  • 김수진 (서울대학교 의과대학 정신과학교실) ;
  • 김붕년 (서울대학교 의과대학 소아.청소년정신과) ;
  • 조수철 (서울대학교 의과대학 소아.청소년정신과) ;
  • 강제욱 (서울대학교 의과대학 소아.청소년정신과) ;
  • 김재원 (서울대학교 의과대학 소아.청소년정신과) ;
  • 신민섭 (서울대학교 의과대학 소아.청소년정신과) ;
  • 정광모 (서울대학교 의과대학 소아.청소년정신과) ;
  • 김효원 (서울대학교 의과대학 소아.청소년정신과)
  • Kim, Su-Jin (Department of Neuropsychiatry, Seoul National University College of Medicine) ;
  • Kim, Boong-Nyun (Division of Child and Adolescent Psychiatry, Seoul National University College of Medicine) ;
  • Cho, Soo-Churl (Division of Child and Adolescent Psychiatry, Seoul National University College of Medicine) ;
  • Kang, Je-Wook (Division of Child and Adolescent Psychiatry, Seoul National University College of Medicine) ;
  • Kim, Jae-Won (Division of Child and Adolescent Psychiatry, Seoul National University College of Medicine) ;
  • Shin, Min-Sup (Division of Child and Adolescent Psychiatry, Seoul National University College of Medicine) ;
  • Cheong, Kwang-Mo (Division of Child and Adolescent Psychiatry, Seoul National University College of Medicine) ;
  • Kim, Hyo-Won (Division of Child and Adolescent Psychiatry, Seoul National University College of Medicine)
  • 투고 : 2009.05.15
  • 심사 : 2009.07.29
  • 발행 : 2009.10.30
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초록

Objectives : Autism is a well-known psychiatric disorder that is presumed to have a neural basis. To investigate the underlying neurofunctional abnormalities of autism, the authors performed single photon emission computed tomography (SPECT) on children with autism. Methods : Fifty-five children with untreated autism (47 boys and 8 girls, mean age=$50.6{\pm}20.28$ months) were selected from among the patients visiting the child and adolescent psychiatric clinic of Seoul National University Hospital. Psychiatrists had diagnosed the participants according to the DSM-IV criteria for autistic disorder and the Childhood Autism Rating Scale (CARS) criteria for a diagnosis of autism. All participants were examined using 99mTC-HMPAO Brain SPECT. Using statistical parametric mapping (SPM) analysis, we compared the participants' SPECT images to standardized SPECT images of normal children, which had been retrospectively selected by the authors, on a voxel by voxel basis. Voxels with a p-value less than .001 were considered to be significantly different. Results : The autistic group showed significant hypoperfusion in the right medial frontal gyrus, right precentral gyrus, and left precuneus gyrus. In addition, they showed no significant hyperperfusion areas when compared to the control group. Conclusion : The findings of hypoperfusion in the medial-frontal lobe and precuneus are accord with hemodynamic abnormalities that have been already reported. Therefore, these findings are compatible with the recently suggested "theory of mind" hypothesis and the disturbances in attention shifting that have been observed in autistic children.

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