Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
권호 표지

The effects of bone regeneration in rabbit calvarial defect with particulated and block type of hydroxyapatite

토끼 두개골 결손부에서 블록형과 분말형 hydroxyapatite의 골전도 효과

  • Gu, Sun-Ja (Department of Periodontology, Research institute of periodontal regeneration, College of Dentistry, Yonsei University) ;
  • Sohn, Joo-Yeon (Department of Periodontology, Research institute of periodontal regeneration, College of Dentistry, Yonsei University) ;
  • Lim, Hyun-Chang (Department of Periodontology, Research institute of periodontal regeneration, College of Dentistry, Yonsei University) ;
  • Um, Yoo-Jung (Department of Periodontology, Research institute of periodontal regeneration, College of Dentistry, Yonsei University) ;
  • Jung, Ui-Won (Department of Periodontology, Research institute of periodontal regeneration, College of Dentistry, Yonsei University) ;
  • Kim, Chang-Sung (Department of Periodontology, Research institute of periodontal regeneration, College of Dentistry, Yonsei University) ;
  • Lee, Yong-Keun (Department and Research Institute of Dental Biomaterials and Bioengineering, College of Dentistry, Yonsei University) ;
  • Choi, Seong-Ho (Department of Periodontology, Research institute of periodontal regeneration, College of Dentistry, Yonsei University)
  • 구순자 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 손주연 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 임현창 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 엄유정 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 정의원 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 김창성 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 이용근 (연세대학교 치과대학 치과생체재료공학교실) ;
  • 최성호 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소)
  • Published : 2009.09.30
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Abstract

Purpose: The purpose of this study was to evaluate the bone regeneration of particulated hydroxyapatite(HA) and block type of hydroxyapatite graft in rabbit calvarial defects. Methods: An 8 mm calvarial circular defects were created in sixteen young adult New Zealand white male rabbits (weight $3.0{\sim}3.5kg$). Each defects were filled with Bio-Oss, particulated HA and block type HA. Sham surgery control defects were filled with blood clots. The specimens were harvested at 4 weeks and 8 weeks for histologic and histomorphometric evaluation. Results: Histomorphometric analysis demonstrated statistical differences in defect closure, new bone formation, and bone density of the four groups. Block type of HA group showed increased bone formation and bone density at 4 weeks and 8 weeks compared with Bio-Oss group or sham surgery control group(p<0.05). Conclusions: Block type of HA is an effective material for osteoconduction in rabbit calvarial defects, which may acts as a guide in use of these products in human application.

Keywords

References

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