Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Distribution of Human Papillomavirus Type 58 Variants in Progression of Cervical Dysplasia in Korean Women

  • Bae, Jeong-Hoon (Department of Obstetrics and Gynecology, The Catholic University of Korea) ;
  • Cheung, Jo L.K. (Department of Microbiology, The Chinese University of Hong Kong) ;
  • Lee, Sung-Jong (Department of Obstetrics and Gynecology, The Catholic University of Korea) ;
  • Luk, Alfred C.S. (Department of Microbiology, The Chinese University of Hong Kong) ;
  • Tong, Seo-Yun (Department of Obstetrics and Gynecology, East-West Neo Medical Center, Kyung-Hee University School of Medicine) ;
  • Chan, Paul K.S. (Department of Microbiology, The Chinese University of Hong Kong) ;
  • Park, Jong-Sup (Department of Obstetrics and Gynecology, The Catholic University of Korea)
  • Published : 2009.09.30
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Abstract

This cross-sectional study examined the distribution of HPV 58 sequence variation in Korean women for the first time. Among 1,750 Korean women, 53 women were positive for HPV 58 single infection, of whom 26 were without disease, 20 were with cervical intraepithelial neoplasia (CIN) 1, and 7 with CIN 2 or 3. Altogether, 36 different nucleotide sequence variations were identified with the L1, 20 within E2, 5 within E6, and 10 within E7. Further studies on variants of oncogenic HPVs are necessary, particularly for the purpose of developing more predictive HPV detection methods.

Keywords

References

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