Korean Journal of Fisheries and Aquatic Sciences (한국수산과학회지)

The Korean Society of Fisheries and Aquatic Science (한국수산과학회)
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Residues of Fluoroquinolones in Olive Flounder (Paralichthys olivaceus) and Black Rockfish (Sebastes schlegell) Following Oral Administration

Fluoroquinolone계 항생제의 경구투여에 따른 양식넙치 및 조피볼락의 체내 잔류량의 변화

  • Kim, Poog-Ho (Food and Safety research center, National Fisheries Research and Development Institute) ;
  • Lee, Doo-Seog (Food and Safety research center, National Fisheries Research and Development Institute) ;
  • Kim, Jin-Woo (Aquatic animal disease control center, National Fisheries Research and Development Institute) ;
  • Park, Mi-Seon (Research and development planning department, National Fisheries Research and Development Institute) ;
  • Kim, Dong-Soo (Dept. of Food science and Technology, Kyungsung University) ;
  • Jo, Mi-Ra (Food and Safety research center, National Fisheries Research and Development Institute)
  • 김풍호 (국립수산과학원 식품안전연구단) ;
  • 이두석 (국립수산과학원 식품안전연구단) ;
  • 김진우 (국립수산과학원 동물방역센터) ;
  • 박미선 (국립수산과학원 연구기획부) ;
  • 김동수 (경성대학교 식품생명공학과) ;
  • 조미라 (국립수산과학원 식품안전연구단)
  • Published : 2009.08.31
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Abstract

The residues of fluoroquinolones in Olive flounder (Paralichthys olivaceus) and Black rockfish (Sebastes schlegeli) were investigated after oral doses of 20 mg/kg for 30 days. Blood samples were taken at 5 hours, 10 hours, 1 day, 2 days, 3 days, 5 days, 7 days, 9 days, 13 days, 20 days and 30 days after treatment. The concentrations of fluoroquinolones were detected by high performance liquid chromatography using a UV detector. The recovery rates of fluoroquinolones in fish samples ranged from 92.0-99.7%, 93.4-97.5% and 93.0-97.9% for treatment of 0.1, 0.5, and $1.0{\mu}g/g$, respectively. Ciprofloxacin, enrofloxacin, norfloxacin and sarafloxacin were detected in the blood of the olive flounder at 10 hours, 10 hours, 1 day and 10 hours after treatment with $6.43{\mu}g/g$, $6.07{\mu}g/g$, $11.83{\mu}g/g$ and $11.02{\mu}g/g$ as maximum level, respectively. Ciprofloxacin, enrofloxacin, norfloxacin and sarafloxacin were detected in the blood of black rockfish 1 day, 1 day, 1 day and 10 hours after treatment with $8.26{\mu}g/g$, $8.03{\mu}g/g$, $7.29{\mu}g/g$ and $9.38{\mu}g/g$ as maximum level, respectively. However, ciprofloxacin, enrofloxacin, norfloxacin and sarafloxacin were not detected in olive flounder samples at 20, 30, 20 and 20 days after treatment in any experiments (

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