Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
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Association of Blood Pressure Levels with Carotid Intima-Media Thickness and Plaques

혈압 수준과 경동맥 내중막 두께 및 동맥경화반의 관련성

  • Lee, Young-Hoon (Department of Preventive Medicine, College of Medicine, Seonam University) ;
  • Kweon, Sun-Seog (Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital) ;
  • Choi, Jin-Su (Department of Preventive Medicine, Chonnam National University Medical School) ;
  • Rhee, Jung-Ae (Department of Preventive Medicine, Chonnam National University Medical School) ;
  • Choi, Sung-Woo (Department of Preventive Medicine, Chonnam National University Medical School) ;
  • Ryu, So-Yeon (Department of Preventive Medicine, Chosun University College of Medicine) ;
  • Shin, Min-Ho (Department of Preventive Medicine, Chonnam National University Medical School)
  • 이영훈 (서남대학교 의과대학 예방의학교실) ;
  • 권순석 (화순전남대학교병원 전남지역암센터) ;
  • 최진수 (전남대학교 의과대학 예방의학교실) ;
  • 이정애 (전남대학교 의과대학 예방의학교실) ;
  • 최성우 (전남대학교 의과대학 예방의학교실) ;
  • 류소연 (조선대학교 의과대학 예방의학교실) ;
  • 신민호 (전남대학교 의과대학 예방의학교실)
  • Published : 2009.09.30
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Abstract

Objectives : The aim of this study was to investigate the association of blood pressure levels with the common carotid artery intima-media thickness (CCA-IMT) and carotid plaques. Methods : Data were obtained from 2,635 subjects, aged 50 years and over, who participated in the Community Health Survey (a population-based, cross-sectional study) in Dong-gu, Gwangju city between 2007 and 2008. Participants were categorized into three groups according to blood pressure levels; normotensives (<120/80 mmHg), prehypertensives (120-139/80-89 mmHg), and hypertensives ($\geq$140/90 mmHg). Prehypertensives were further categorized as low prehypertensives (120-129/80-84 mmHg) and high prehypertensives (130-139/85-89 mmHg). Carotid intima-media thickness and plaques were evaluated with a high-resolution B-mode ultrasound. Statistical analyses were performed using chi-square test, ANOVA, and multiple logistic regression. Results : Prehypertensives had significantly greater maximal CCA-IMT values than normotensives, with a multivariate adjusted odds ratio of 1.78 (95% CI=1.36-2.32) for abnormal CCA-IMT (maximal CCA-IMT$\geq$1.0 mm), and 1.45 (95% CI=1.19-1.77) for carotid plaques. The multivariate adjusted odds ratio of low prehypertensives was 1.64 (95% CI=1.21-2.21) for abnormal CCA-IMT, and 1.30 (95% CI=1.04-1.63) for carotid plaques compared with normotensives. Subject with hypertension had higher frequency of abnormal CCA-IMT (odds ratio, 2.18; 95% CI=1.49-3.18), and carotid plaques (odds ratio, 1.98; 95% CI=1.46-2.67) compared with normotensives after adjustment for other cardiovascular risk factors. Conclusions : Our results indicate that there is a significant increase in the prevalence of carotid atherosclerosis in subjects with prehypertension (even in low prehypertensives) compared with normotensive subjects. Further studies are required to confirm the benefits and role of carotid ultrasonography in persons with prehypertension.

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