Nuclear Medicine and Molecular Imaging

The Korean Society of Nuclear Medicine (대한핵의학회)
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A Neurofibroma Confused with Sarcomatous Transformation on F-18 FDG PET/CT in Neurofibromatosis-1

신경섬유종증 환자의 F-18 FDG PET/CT에서 육종전환으로 오인된 신경섬유종

  • Park, Soon-Ah (Department of Nuclear Medicine, Wonkwang University College of Medicine) ;
  • Song, Jeong-Hoon (Department of Plastic and Reconstructive Surgery, Wonkwang University College of Medicine) ;
  • Yang, Chung-Yong (Department of Physical Medicine and Rehabilitation, Wonkwang University College of Medicine) ;
  • Kim, Hun-Soo (Department of Pathology, Wonkwang University College of Medicine) ;
  • Park, Seung-Chol (Department of Urology, Wonkwang University College of Medicine)
  • 박순아 (원광대학교 의과대학 핵의학과) ;
  • 송정훈 (원광대학교 의과대학 성형외과) ;
  • 양충용 (원광대학교 의과대학 재활의학과) ;
  • 김헌수 (원광대학교 의과대학 병리과) ;
  • 박승철 (원광대학교 의과대학 비뇨기과)
  • Published : 2009.08.30
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Abstract

We present a patient with high $^{18}$F-fluorodeoxyglucose (FDG) uptake detected in a neurofibroma that was confused with sarcomatous transformation on a positron emission tomography/computed tomography (PET/CT) scan. A 39-year-old male patient with a 20-year history of neurofibromatosis-1 (NF-1) performed FDG PET/CT scan for the evaluation of lesions with sarcomatous transformation. The FDG PET/CT images demonstrated varying degrees of increased FDG uptake in the multiple nodules throughout whole body. The left pelvic mass with the highest FDG uptake had a maximum standardized uptake values (maxSUV) 5.0 and surgical resection was performed. Histological analysis confirmed the presence of a benign neurofibroma infiltrated with inflammatory cells.

Keywords

References

  1. Ramanathan RC, Thomas JM. Malignant peripheral nerve sheath tumours associated with von Recklinghausen's neurofibromatosis. Eur J Surg Oncol 1999;25:190-3 https://doi.org/10.1053/ejso.1998.0625
  2. Son JM, Ahn MI, Cho KD, Yoo J, Park YH Varying degrees of FDG uptake in multiple benign neurofibromas on PET/CT. Br J Radiol 2007;80:222-6 https://doi.org/10.1259/bjr/31510627
  3. Cardona S, Schwarzbach M, Hinz U, Dimitrakopoulou-Strauss A, Attigah N, Mechtersheimer section sign G, et al. Evaluation of $^{18}$F-deoxyglucose positron emission tomography (FDG-PET) to assess the nature of neurogenic tumours. Eur J Surg Oncol 2003;29:536-41 https://doi.org/10.1016/S0748-7983(03)00055-6
  4. Basu S, Nair N. Potential clinical role of FDG-PET in detecting sarcomatous transformation in von Recklinghausen's disease: a case study and review of the literature. J Neurooncol 2006;80:91-5 https://doi.org/10.1007/s11060-006-9161-x