Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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Effects of Pinelliae Rhizoma Extract on Sociopsychological Stress

반하(半夏) 추출물이 생쥐의 사회.심리적 스트레스에 미치는 영향

  • Kim, Su-Youn (College of Oriental Medicine, Dong-Shin University) ;
  • Lim, Se-Hyun (College of Nursing, Korea University) ;
  • Cho, Su-In (School of Oriental Medicine, Pu-San National University) ;
  • Choi, Chang-Won (College of Oriental Medicine, Dong-Shin University) ;
  • Kim, Kyeong-Ok (College of Oriental Medicine, Dong-Shin University)
  • 김수연 (동신대학교 한의과대학) ;
  • 임세현 (고려대학교 간호대학) ;
  • 조수인 (부산대학교 한의학전문대학원) ;
  • 최창원 (동신대학교 한의과대학) ;
  • 김경옥 (동신대학교 한의과대학)
  • Published : 2009.09.30
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Abstract

Objectives : The effects of Pinelliae Rhizoma extract(PRe) were tested for the anti-stress action. Methods : PRe was fed to ICR male mice($20{\pm}2g$) orally with the dose of 100 mg/kg/day for five days. Mice were exposed to sociopsychological stress by restraining and seeing foot shock stressed mice for one hour for five days. Results : PRe administration had the effect of decreasing serum level of lipid peroxidation. The elevated plus-maze test is designed to detect the effect of anxiolytic drugs, and PRe administration group showed a significant increase of latency time. From Microarray, common features between mind-stimulus related genes and body-stimulus related genes were not so abundant When PRe was administered, there were some changes in distributions of mind-stimulus related genes but the distributions were not recovered to normal status. Conclusions : These results suggest that PRe can effectively rid the sociopsychological stress and stress concrened diseases.

Keywords

References

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