Korean Journal of Acupuncture

  • 제26권2호
  • /
  • Pages.127-143
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  • 2009
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  • 2287-3368(pISSN)
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  • 2287-3376(eISSN)
경락경혈학회 (Society for Meridian and Acupoint)
권호 표지

음곡 차전자 약침이 LPS로 유도된 흰쥐의 신장염에 미치는 영향

Anti-inflammatory Effect of Plantaginis Semen Herbal-acupuncture at KI10 on LPS-induced nephritis in rats

  • 박병문 (대전대학교 한의과대학 경락경혈학교실) ;
  • 허부 (대전대학교 한의과대학 경락경혈학교실) ;
  • 임윤경 (대전대학교 한의과대학 경락경혈학교실)
  • Park, Byong-Mun (Dept. of Meridian & Acupoint, College of Oriental Medicine, Daejeon University) ;
  • Hur, Boo (Dept. of Meridian & Acupoint, College of Oriental Medicine, Daejeon University) ;
  • Yim, Yun-Kyoung (Dept. of Meridian & Acupoint, College of Oriental Medicine, Daejeon University)
  • 발행 : 2009.06.27
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초록

Objective : This study aimed to evaluate the effects of Plantaginis Semen herbal-acupuncture (PS-HA) at KI10 (Umgok) on nephritis induced by lipopolysaccharide (LPS) in rat. Methods : The authors performed several experimental items including measurements of urinary volume, WBC in blood, BUN, creatine, TNF-$\alpha$, CINC-1 in serum, creatinine, total protein in urine, TNF-$\alpha$, MPO in kidney and histological analysis of renal tissue. Results : PS-HA at KI10 significantly reduced WBC in blood, BUN, TNF-$\alpha$ in serum of LPS-stimulated rats. PS-HA at KI10 significantly increased urinary volume in LPS-stimulated rats. And PS-HA at KI10 significantly reduced MPO in kidney of LPS-stimulated rats. Conclusion : Taken together, PS-HA at KI10 has a therapeutic effect on nephritis in LPS-stimulated rat. Therefore, it is suggested that PS-HA at KI10 may be an useful therapeutics for nephritis in clinical field.

키워드

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