Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Case of Sarcoidosis with Pancytopenia as Resulting from Bone Marrow Involvement

골수를 침윤하여 범혈구감소증을 나타낸 유육종증 1예

  • Park, Tai Sun (Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Kim, Dae-Young (Department of Hematology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Park, Seo-Jin (Department of Laboratory Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Kim, Yi Rang (Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Na, Soo Young (Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Park, Jin Wook (Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Oh, Dong Wook (Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Choi, Jun Seok (Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Jo, Jung Min (Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Chang, Youjin (Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Kim, Won Young (Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Choi, Chang-Min (Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center)
  • 박태선 (울산대학교 의과대학 서울아산병원 호흡기내과학교실) ;
  • 김대영 (울산대학교 의과대학 서울아산병원 혈액내과학교실) ;
  • 박서진 (울산대학교 의과대학 서울아산병원 진단검사의학교실) ;
  • 김이랑 (울산대학교 의과대학 서울아산병원 호흡기내과학교실) ;
  • 나수영 (울산대학교 의과대학 서울아산병원 호흡기내과학교실) ;
  • 박진욱 (울산대학교 의과대학 서울아산병원 호흡기내과학교실) ;
  • 오동욱 (울산대학교 의과대학 서울아산병원 호흡기내과학교실) ;
  • 최준석 (울산대학교 의과대학 서울아산병원 호흡기내과학교실) ;
  • 조정민 (울산대학교 의과대학 서울아산병원 호흡기내과학교실) ;
  • 장유진 (울산대학교 의과대학 서울아산병원 호흡기내과학교실) ;
  • 김원영 (울산대학교 의과대학 서울아산병원 호흡기내과학교실) ;
  • 최창민 (울산대학교 의과대학 서울아산병원 호흡기내과학교실)
  • Received : 2009.09.28
  • Accepted : 2009.10.06
  • Published : 2009.12.30
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Abstract

Sarcoidosis is a granulomatous disease that can involve any organ, although it primarily involves the lungs, intrathoracic lymph nodes, skin, and eyes. We present a case of sarcoidosis with pancytopenia, resulting from bone marrow involvement. A 35-year-old man was admitted to hospital for chronic cough and blurred vision. On chest computed tomography, there were multiple pulmonary nodules and mediastinal lymph nodes enlargement. As the patient also showed pancytopenia, we performed a bone marrow biopsy, as well as a transbronchial lung biopsy. Both biopsies showed non-caseating granulomas. We diagnosed the patient with sarcoidosis with pulmonary, bone marrow, uvea, liver and spleen involvement. After oral steroid therapy, the patient's symptoms as well as his pancytopenia improved. We present this case to demonstrate the significance of bone marrow biopsy in cases of sarcoidosis with pancytopenia, as well the possibility of clinical improvement with steroid treatment.

Keywords

References

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