Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Case of Extramedullary Hematopoiesis Presenting as a Lung Mass in a Patient with Primary Myelofibrosis

폐 종괴로 나타난 원발성 골수섬유증 환자의 골수 외 조혈 1예

  • Kim, Yeo Myeong (Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences) ;
  • Kim, Hyeon Tae (Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences) ;
  • Noh, Geum Youb (Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences) ;
  • Kang, Min Soo (Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences) ;
  • Chang, Yoon Hwan (Department of Laboratory Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences) ;
  • Kim, Hye-Ryoun (Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences) ;
  • Lee, Jae Cheol (Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences) ;
  • Kim, Cheol Hyeon (Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences)
  • 김여명 (한국원자력의학원 원자력병원 내과) ;
  • 김현태 (한국원자력의학원 원자력병원 내과) ;
  • 노금엽 (한국원자력의학원 원자력병원 내과) ;
  • 강민수 (한국원자력의학원 원자력병원 내과) ;
  • 장윤환 (한국원자력의학원 원자력병원 진단검사의학과) ;
  • 김혜련 (한국원자력의학원 원자력병원 내과) ;
  • 이재철 (한국원자력의학원 원자력병원 내과) ;
  • 김철현 (한국원자력의학원 원자력병원 내과)
  • Received : 2009.07.29
  • Accepted : 2009.09.02
  • Published : 2009.09.30
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Abstract

Primary myelofibrosis is characterized by replacement of bone marrow with fibrotic tissue and the development of extramedullary hematopoiesis. Extramedullary hematopoiesis primarily involves the spleen and liver, but can also occur in the lungs. We report the case of an 80-year-old male who was admitted for evaluation of a lung mass and persistent thrombocytopenia. A percutaneous needle aspiration from the mass in the right lower lung showed myelopoietic cells with fatty tissue. A bone marrow biopsy revealed a hypercellular marrow with an increased number of atypical megakaryocytes. The final diagnosis was a prefibrotic stage of primary myelofibrosis leading to extramedullary hematopoiesis in the lung.

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References

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