Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Case of Isoniazid Induced Gynecomastia

이소니아지드에 의한 여성형 유방 1예

  • Lee, Min Kyung (Divisions of Pulmonary Medicine, Department of Internal Medicine, Eulji University School of Medicine) ;
  • Na, Dong Jib (Divisions of Pulmonary Medicine, Department of Internal Medicine, Eulji University School of Medicine) ;
  • Jeon, Ho Seok (Divisions of Pulmonary Medicine, Department of Internal Medicine, Eulji University School of Medicine) ;
  • Lee, Yang Deok (Divisions of Pulmonary Medicine, Department of Internal Medicine, Eulji University School of Medicine) ;
  • Cho, Yong Seon (Divisions of Pulmonary Medicine, Department of Internal Medicine, Eulji University School of Medicine) ;
  • Han, Min Soo (Divisions of Pulmonary Medicine, Department of Internal Medicine, Eulji University School of Medicine) ;
  • Yoon, Hee Jeong (Divisions of Infectious Medicine, Department of Internal Medicine, Eulji University School of Medicine)
  • 이민경 (을지대학교 의과대학 내과학교실 호흡기내과) ;
  • 나동집 (을지대학교 의과대학 내과학교실 호흡기내과) ;
  • 전호석 (을지대학교 의과대학 내과학교실 호흡기내과) ;
  • 이양덕 (을지대학교 의과대학 내과학교실 호흡기내과) ;
  • 조용선 (을지대학교 의과대학 내과학교실 호흡기내과) ;
  • 한민수 (을지대학교 의과대학 내과학교실 호흡기내과) ;
  • 윤희정 (을지대학교 의과대학 내과학교실 감염내과)
  • Received : 2008.09.30
  • Accepted : 2008.11.17
  • Published : 2009.01.30
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Abstract

We emphasizes the fact that isoniazid could lead to the development of gynecomastia. Physicians should be aware of this rare adverse effect.

약제에 의한 여성형 유방 원인 중 isoniazid에 의한 경우는 매우 드물다. 저자들은 72세 폐결핵 환자에서 항결핵제 복용 4개월 후 양측에 여성형 유방이 발생한 증례를 보고 한다. 다른 특별한 원인이 없으며 유방 조영술과 초음파 검사상 특이 소견 관찰 되지 않아 원인 약제 중 최근 복용중인 isoniazid에 의한 여성형 유방으로 추정하고 isoniazid를 제외한 항결핵제를 계속 투여한 후 점차 호전되었다.

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References

  1. Girling DJ. Adverse effects of antituberculosis drugs. Drugs 1982;23:56-74 https://doi.org/10.2165/00003495-198223010-00003
  2. Braunstein GD. Gynecomastia. N Engl J Med 1993;328:490-5 https://doi.org/10.1056/NEJM199302183280708
  3. Guinet P, Garin JP, Morneix A. Gynecomastia in a grave case of pulmonary tuberculosis during isonicotinic acid hydrazide therapy. Lyon Med 1953;188:281-4
  4. Bergogne-Berezin E, Nouhouayi A, Letonturier P, Thibault B, Tourneur R. Gynecomastia caused by isoniazid. Value of determination of the inactivation phenotype. Nouv Presse Med 1976;5:213-4
  5. Khanna P, Panjabi C, Maurya V, Shah A. Isoniazid associated painful, bilateral gynecomastia. Indian J Chest Dis Allied Sci 2003;45:277-9
  6. Dixit R, Sharma S, Nawal CL. Gynaecomastia during antituberculosis chemotherapy with isoniazid. J Assoc Physicians India 2008;56:390-1
  7. Williams MJ. Gynecomastia: its incidence, recognition and host characterization in 447 autopsy cases. Am J Med 1963;34:103-12 https://doi.org/10.1016/0002-9343(63)90044-5
  8. Bowers SP, Pearlman NW, McIntyre RC Jr, Finlayson CA, Huerd S. Cost-effective management of gynecomastia. Am J Surg 1998;176:638-41 https://doi.org/10.1016/S0002-9610(98)00281-5
  9. Thompson DF, Carter JR. Drug-induced gynecomastia. Pharmacotherapy 1993;13:37-45
  10. Chunhaswasdikul B. Gynecomastia in association with administration of thiacetazone in the treatment of tuberculosis. J Med Assoc Thai 1974;57:323-7

Cited by

  1. Isoniazid related gynecomastia: Description of a case and systematic review of literature vol.29, pp.2, 2009, https://doi.org/10.4103/0970-2113.95343