생명과학회지 (Journal of Life Science)

  • 제19권9호
  • /
  • Pages.1265-1270
  • /
  • 2009
  • /
  • 1225-9918(pISSN)
  • /
  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
권호 표지
DOI QR코드

DOI QR Code

능이 버섯이 고지방식이에 의한 고지혈증 비만 쥐에 미치는 영향

Effects of the Sarcodon aspratus on the High Level of Blood Lipid and Obesity Induced by High Fat-diet in Rat

  • 이경숙 (대구가톨릭대학교 대학원 생물학과) ;
  • 김종봉 (대구가톨릭대학교 대학원 생물학과)
  • Lee, Kyung-Suk (Department of Biology, The Graduate School, Catholic University of Daegu) ;
  • Kim, Jong-Bong (Department of Biology, The Graduate School, Catholic University of Daegu)
  • 발행 : 2009.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

능이버섯의 항비만 건강식품으로서의 이용가능성을 분석하였다. 고지방식이에 의해 유도된 비만쥐에 6주 동안 능이버섯 분말을 섭취시켜, 능이버섯의 효과를 알아보기 위하여 비만지수, 혈청지질, 장기무게 등의 여러 가지 요인들을 분석하였다. 고지방식이를 먹인 쥐 혈청의 중성지방, 총콜레스테롤 및 Ldl은 유의적으로 증가하였으나 능이버섯분말을 먹인 쥐는 증가하지 않았다. 고지방식이 쥐에서 R$\ddot{o}$hrer index는 대조군에 비해 유의적으로 증가하였으나 버섯 분말을 섭취한 쥐는 R$\ddot{o}$hrer index가 유의적으로 감소하였다. 특히 몸무게에 대한 간 무게의 비율은 대조군에 비해 비만식이 쥐에서 높았다. 이러한 결과들은 버섯을 먹인 쥐에서의 비만지수와 장기무게의 유의적인 변화는 혈청에서 중성지방의 감소 때문인 것으로 생각된다. 그렇기 때문에 능이버섯은 비만과 관련된 질병을 막을 수 있는 건강식품의 하나로 이용 될 수 있는 가능성이 있다.

The mushroom, Sarcodon aspratus was tested for its possibility of being a health food against corpulence. The mushroom powder was fed to rats with high-fat diet-induced corpulence for 6 weeks. To measure its effects, various factors such as obesity index, serum lipid, and organ weight were analyzed and compared. The group fed a high-fat diet showed a significant increase in the levels of triglyceride, total cholesterol and LDL-cholesterol in serum. However, this increase was not shown in the group fed mushroom powder. The R$\ddot{o}$hrer index (one of many obesity indexes) was higher in the group fed a high-fat diet compared to that of control group. However, there was a significant decrease in the R$\ddot{o}$hrer index in the group fed with mushroom powder. Especially, the increased ratio of liver to body weight was observed in the group fed a high-fat diet compared to the control group. These results suggest that the significant changes in obesity index and organ weight in the group fed with mushroom powder are due to the decreased level of serum triglyceride. Thus, there is a possibility for Sarcodan aspratus to become a heath food that can prevent diseases related to corpulence.

키워드

참고문헌

  1. Allain, C. C., L. S. Poon, C. S. Chan, W. Richmond, and P. C. Fu. 1974. Enzymatic determination of total serum cholesterol. Clin. Chem. 20, 470-475
  2. Dubuc, P. U. 1981. Non-essential role of dietary factors in the development of diabetes in obi obmice. J. Nutr. 111, 1742-1748
  3. Eun, J. S., J. H. Yang, D. Y. Cho, and T. K. Lee. 1988. Studies on fungi in Korea (1). The activity of proteolytic enzyme from Sarcodon aspratus (Berk) S. Ito. J. Kor. Pham. Sci. 18, 125-131
  4. Fridwald, W. T., R. I. Levy, and D. S. Fredrickson. 1972. Estimation of the concentration of the low-density lipoprotein cholesterol in plasma without use of the preparative ultracen-trifuge. Clin. Chem. 18, 499-502
  5. Gaiva, M. H, R. C. Couto, L. M. Oyama, G. E. Couto, V. K. Silveira, E. B. Riberio, and C. M. Nascimento. 2001. Polyunsaturated fatty acid rich diets: effet on adipose tissue metabolism in rats. Brj. Nutr. 8, 371-377
  6. Gordon, T., W. B. Kannel, W. P. Castelli, and T. R. Dawber. 1981. Lipoproteins cardiovascular disease and death. The Framimgham study. Arch. Intem. Med. 141, 1158-1131
  7. Gotto, A. M. and J. A. Farmer. 2006. Drug insight: The role of statins in combination with ezetimibe to lower Ldl-cholesterol. Nat. Clin. Pract. Cardiovasc. Med. 3, 664-672 https://doi.org/10.1038/ncpcardio0711
  8. Hue, G. B. 1990. Pathology of obesity. Korean J. Nutr. 23, 333-336
  9. Jong, S. C. and R. Donivick. 1989. Antitumor and antiviral substance from fungi. Aduances in applied microbiology. 34, 183-262 https://doi.org/10.1016/S0065-2164(08)70319-8
  10. Kang, H c., B. D. Yun, S. H. Yu, and I. C. Yoo. 2000. Chemical structure of the compound isolsted from the mushroom Sarcodon asparatus. Can. J. Chem. 65, 2369-2372
  11. Kang, T. S., M. S. Kang, J. M. Sung, A. S. Kang, H R. Shon, and S. Y. Lee. 2001. Effect of Pleurotus eryngii on the blood glucose and cholesterol in diabetic rats. Korean J. Soc. Mycology 29, 86-90
  12. Kim, H S. and C. J. Sung. 2001. Effects of dietary zinc and iron levels on serum trace minerals and obesity index in high diet-induced obese rats. J. Korean Soc. Food Sci. Nutr. 30, 325-330
  13. Kim, J. K. and M. K. Kim. 2007. Effects of lysine-limited diets containing levels of L-carnitine on body weight and lipid metabolism in obesity- induced adult rats. J. Korean Soc. Food Sci. Nutr. 40, 118-129
  14. Koh, J. B. and M. A. Choi. 2001. Effect of Cordyceps militaris on lipid metabolism in rats fed cholesterol diet. Korean J. Nutrition 34, 265-270
  15. Lee, J. S., K. H Lee, and J. H Jeong. 1999. Effects of extract of pueraria radix on lipid metabolism in rats fed high fat diet. J. Korean Soc. Food Sci. Nutr. 28, 218-224
  16. Lee, J. M., W. K. Cho, and H J. Park. 1998. Effects of chitsan treated with enzymatic methods on glucose and lipid metabolism in rats. Korean J. Nutr. 31, 1112-1120
  17. Lee, S. H, N. W. Kim, and S. R. Shin. 2003. Studies on the nutritonal components of mushroom (Sarcodon asprstus). Korean J. Food Preserv. 10, 65-69
  18. Nilsson-Ehie, P., A. S. Garfinkel, and M. C. Schotz. 1980. Lipolytic enzymes and plasma lipoprotein metabolosm. Annu. Rev. Biochem. 49, 667-693 https://doi.org/10.1146/annurev.bi.49.070180.003315
  19. Oh, S. W., C. U. Lee, and J. B. Koh. 2004. Effect of Agaricus blzei murill on Lipid metabolism in rats fed high fat diet. J. Korean Soc. Food Sci. Nutr. 33, 821-826 https://doi.org/10.3746/jkfn.2004.33.5.821
  20. Park, H. Y., H D. Yoon, and E. G Oh. 2001. Effect of Meristatheca papulosa on lipid concentration of serum and liver in rats fed high fat diet. J. Korean Soc. Food Sci. Nutr. 30, 107-111
  21. Park, P. S. 1990. Influence of some vegetable seed oil feeds on body lipid composition in rats. Ph D Dissertation, Kyungsang University
  22. Park, S. J. and M. H. Kang. 2003. The effect of dietary noodle with glucomannan on the weight loss in high fat diet-induced obese rats. J. Korean Soc. Food Sci. Nutr. 32, 893-898 https://doi.org/10.3746/jkfn.2003.32.6.893
  23. Sjostrom, L. V. 1992. Morbidity of severely obese subjects. Am. J. Clin. Nutr. 55, 508-515
  24. Tampfer, M. L F. M. Sacks, S. Salvini, W. C. Willett, and C. H. Hennekens. 1991. A prospective study of cholesterot apolipoproteins and the risk of myocardial infarction. N. Engl. J. Med. 325, 373-381 https://doi.org/10.1056/NEJM199108083250601
  25. Stenaland, S. H. and S. Margolis. 1982. Simplifying the calculation of body mass index for quick reference. J. Am. Diet. Assoc. 90, 856
  26. Tsuchimoto, S., Y. Nishimura, and E. Ohtsubo. 1992. The stable maintenance system pem of plasmid R100: degradation of PemI proteinmay allow Pem K protein to inhibit cell growth. J. Bacterial. 174, 4205-4211
  27. Yamamoto, A., H. Temba, H. Horibe, H. Mabuchi, Y. Saito, Y. Matsuzawa, T. Kita, and H. Nakamura. 2003. Life style and cardiovascular risk factors in the Japanese population from an epidemiological survey on serum lipid levels in Japan 1990 part 2. association of lipid parameters with hyper tension. J. Atheroscler. Thromb. 10, 176-185 https://doi.org/10.5551/jat.10.176
  28. Yun, Y. S. and H. S. Park. 2002. E E E E E body mass index change on cardiovascular risk factors in korean men. J. Korean Acad. Fam. Med. 23, 794-803

피인용 문헌

  1. Optimization of Extraction Conditions of Sarcodon aspratus by Response Surface Methodology vol.44, pp.3, 2015, https://doi.org/10.3746/jkfn.2015.44.3.464
  2. Study of Lipoprotein Lipase Inhibitory Activity of Anti-obesity Herb Extracts vol.47, pp.2, 2015, https://doi.org/10.9721/KJFST.2015.47.2.246
  3. Anti-obesity Effects of Black Bean Chungkugjang Extract in 3T3-L1 Adipocytes and Obese Mice Induced by High Fat Diet vol.40, pp.9, 2011, https://doi.org/10.3746/jkfn.2011.40.9.1235
  4. Effects of Fermented Sargassum thunbergii on Platelet Aggregation and Serum Lipid Levels in Obese Rat induced by High Fat Diet vol.25, pp.4, 2015, https://doi.org/10.5352/JLS.2015.25.4.456
  5. Effects of Jebikong (Dolichos lablab) Extract on Serum Lipid Metabolism in Rats Fed a High Fat Diet vol.28, pp.4, 2013, https://doi.org/10.7318/KJFC/2013.28.4.409