한국약용작물학회지 (Korean Journal of Medicinal Crop Science)

  • 제17권4호
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  • Pages.273-279
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  • 2009
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  • 1225-9306(pISSN)
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  • 2288-0186(eISSN)
한국약용작물학회 (The Korean Society of Medicinal Crop Science)
권호 표지

사염화탄소로 간 손상이 유발된 흰쥐에서 황금(黃芩) 열수 추출물이 면역작용에 미치는 효과

The Protective Effects of Scutellaria baicalensis Georgi Water Extracts on the Immunomodulatory Effects on Liver Damage Induced by Carbon Tetrachloride in Rats

  • 안치선 (건국대학교 의료생명대학 생명과학부) ;
  • 김해란 (건국대학교 의료생명대학 생명과학부) ;
  • 전윤희 (건국대학교 의료생명대학 생명과학부) ;
  • 임병우 (건국대학교 의료생명대학 생명과학부)
  • An, Chi-Sun (College of Biomedical & Health Science, Department of Life Science, Konkuk University) ;
  • Jin, Hai-Lan (College of Biomedical & Health Science, Department of Life Science, Konkuk University) ;
  • Jeon, Yun-Hui (College of Biomedical & Health Science, Department of Life Science, Konkuk University) ;
  • Lim, Beong-Ou (College of Biomedical & Health Science, Department of Life Science, Konkuk University)
  • 발행 : 2009.08.30
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초록

GATA-binding protein-3 (GATA-3) and T-box expressed in T-cells (T-bet) are now considered as master transcription factors involving Th cell differentiation, but the roles of these factors are still uncertain in vivo. This study was conducted to investigate the expression of these transcription factors in the liver damage induced by carbon tetrachloride ($CCl_4$) in rats. In this study, liver damage were induced with Scutellaria baicalensis Georgi water extracts (SBW) and followed for 4 weeks. The expression of GATA-3 and T-bet protein in liver damage induced by $CCl_4$ and the serum levels of immunoglobulin A (IgA), IgE were studied after 4 weeks of treatment. We found that effect of SBW on IFN-$\gamma$, STAT1, pSTAT1 and T-bet was decreased in vivo. Several genes were demonstrated to be IL-4 inducible prior to the discovery of STAT6. $CCl_4$+SBW group was significantly lower than $CCl_4$ group in IL-4, STAT6, pSTAT6 and GATA-3. Our data indicate that cytokine protein production were increased in $CCl_4$ group and $CCl_4$+SBW group. From these results, water extracts obtained from Scutellaria baicalensis Georgi may have an immunoregulatory effect in the liver induced by $CCl_4$ of rats.

키워드

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