생명과학회지 (Journal of Life Science)

  • 제19권8호
  • /
  • Pages.1145-1151
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  • 2009
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  • 1225-9918(pISSN)
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  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
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신의대(Sasa coreana Nakai) 추출물이 고콜레스테롤 식이 투여 흰쥐의 혈청 지질에 미치는 영향

Effects of Sasa coreana Nakai on the Lipid Compositions of Serum in High Cholesterol Diet Rats

  • 박종옥 (경성대학교 화학과) ;
  • 장혜원 (성균관 의대 삼성서울병원 내분비대사내과)
  • Park, Jong-Ok (Department of Chemistry, Kyungsung University) ;
  • Jang, Hye-Won (Division of Endocrinology & Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • 발행 : 2009.08.30
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초록

신의대 (Sasa corean, Nakai, 대나무 일종) 추출물이 혈청지질 개선에 미치는 영향을 조사하기 위하여 1.0%의 콜레스테롤 첨가식이로 유발된 고지혈증 Sprague Dawley계 수컷 흰쥐를 이용하였다. 실험동물들은 4 종류 투여군으로 나누었으며 고콜레스테롤 투여군(HC)을 대조군으로 하였고 3 종류의 대나무추출액을 첨가한 투여군(HCW, HCM 및 HCH) 을 실험군으로 하였다. 대나무추출액은 헥산, 메탄올 및 물을 이용하여 순차적으로 추출하여 농축, 동결건조하여 사용하였다. 고콜레스테롤식이를 급여한 대조군(HC 대조군)에 비하여 대나무추출물을 첨가한 모든 투여군(HCW, HCM 및 HCH 투여군)에서 체중변화 및 식이섭취량에 미치는 영향은 별로 크지 않았다. 혈청 총 콜레스테롤 및 LDL-콜레스테롤 함량을 비교하였을 때 HC 대조군에 비하여 대나무추출물 첨가 투여군에서 18.5-23.7% 및 15.7-18.6% 감소하였으며 특히 메탄올추출물의 효과가 가장 높았다. 항동맥경화 인자로 알려진 HDL-콜레스테롤의 경우 대나무추출물 투여군에서 HC 대조군에 비하여 17.2-21.9% 정도 증가하는 것을 볼 수 있었다. 대나무추출물은 고콜레스테롤 식이를 섭취한 HC 대조군에 비하여 동맥경화지수를 낮추는 효과가 있었다(HC group : 2.96${\pm}$0.08, HCM group : 1.48${\pm}$0.02, HCW group : 1.69${\pm}$0.04, HCH group : 1.84${\pm}$0.01). 또한 혈청중의 중성지질 함량 및 인지질 함량도 메탄올추출물 투여군에서 가장 낮았다. 이러한 실험 결과들로부터 대나무 추출물, 특히 메탄올추출물이 혈청지질의 개선효과가 있으며 결과적으로 고지혈증이나 심장순환기계 질환을 예방하는 효과가 있을 것으로 사료된다.

This study was performed to investigate the effects of Sineui-Dae (Sasa coreana Nakai, a kind of bamboo) extracts on the improvement of serum lipid composition by using rats fed a hypercholesterol diet for 4 weeks. The experiment animals were administered with the following diets; high cholesterol diet group (HC diet) as a control and three supplemented groups with high cholesterol diets (HCW, HCM or HCH diet). Three kinds of extracts were prepared by orderly extraction with hexane, methanol, and water. We measured free cholesterol, cholesteryl ester, total cholesterol LDL- and HDL-cholesterol triglyceride and phospholipid in the serum of rats in three experimental and control groups. There were no significant differences in body weights and feed intakes between the HC control group and the extract supplemented groups. The levels of total cholesterol and LDL-cholesterol in the serum of extract supplemented groups were lower than that of the group fed with HC diet only. Serum HDL-cholesterol levet which is known as an antiatherosclerosis factor, was higher in all groups supplemented with bamboo extract by 17.2-21.9% compared to the HC control group. All groups supplemented with bamboo extracts showed the lowering effect of atherogenic index compared to the HC control group (HC group: 2.96${\pm}$0.08, HCM group: 1.48${\pm}$0.02, HCW group: 1.69${\pm}$0.04, HCH group: 1.84${\pm}$0.01). Furthermore, serum triglyceride and phospholipid decreased significantly in the HCM diet compared to the HC control diet. These results suggest that Sineui-Dae bamboo extract, especially methanol extract, has improving effects on hyperlipidemia of rats fed a high cholesterol diet.

키워드

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