Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
권호 표지
DOI QR코드

DOI QR Code

Effect of the Deep Sea Water on the Blood Glucose and the Langerhans' Islet in the STZ-induced type I Diabetic Mice

해양심층수 섭취가 STZ로 유발된 제 1형 당뇨 생쥐의 혈당치 및 췌도에 미치는 영향

  • 정재봉 (경성대학교 이과대학 생물학과) ;
  • 정지윤 (경성대학교 이과대학 생물학과) ;
  • 윤명희 (경성대학교 이과대학 생물학과)
  • Published : 2009.07.30
Download PDF
⟨ Previous Next ⟩

Abstract

Effects of deep sea water on blood glucose and the Langerhans' islet in STZ-induced type I diabetic mice were investigated. Results showed that diabetic symptoms in STZ-induced diabetic mice improve with a supplement of deep sea water. That is, the level of blood glucose was lower, the area of the Langerhan' islet was wider, and the number of pancreatic $\beta$-cells was larger in the diabetic mice supplied with deep sea water than in the diabetic mice supplied with tap water. Such effects might be related to the high level of Mg$^{2+}$ in the deep sea water.

STZ(Streptozotocin)를 이용하여 제 1형 당뇨를 유발시킨 생쥐에게 해양심층수를 음용시켜, 혈당치의 변화 및 파괴된 췌도에 미치는 영향에 대하여 연구하였다. 그 결과 수돗물을 음용시킨 생쥐에 비해서 해양심층수를 음용시킨 생쥐의 혈당이 낮아지고, 파괴되었던 췌도의 면적이 넓어졌으며, 췌도 내에 정상적인 $\beta$-세포의 수도 많아진 점으로부터, 해양심층수의 음용이 당뇨병의 증상완화에 효과가 있음이 밝혀졌다. 이러한 효과는 해양심층수에 포함된 $Mg^{2+}$의 효과인 것으로 생각되었다.

Keywords

References

  1. Anetor, J. I., A. Senjobi, O. A. Aiose, and E. O. Agbedana. 2002. Decreased serum magnesium and zinc levels: atherogen implications in type-2 diabetes mellitus in Nigerians. Nutr. health 16, 291-300 https://doi.org/10.1177/026010600201600403
  2. Barbagallo, M., L. J. Dominguez, A. Galioto, A. Ferlisi, C. Cani, L. Malfa, A. Pineo, A. Busardo, and G. Paolisso. 2003. Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X. Molecular Aspects of Medicine 24,39-52 https://doi.org/10.1016/S0098-2997(02)00090-0
  3. Djurhuus, M. S., N. A. Klitgaard, K. K. Pedersen, O. Blaabjerg, B. M. Altura, and J. E. Henriksen. 2001. Magnesium reduces insulin-stimulated glucose uptake and serum lipid concentrations in type 1 diabetes. Metabolism 50, 1409-1417 https://doi.org/10.1053/meta.2001.28072
  4. Fung, T. T., J. E. Manson, C. G. Solomon, S. Liu, W. C. Willett, and F. B. Hu. 2003. The association between magnesium intake and fasting insulin concentration in healthy middle-aged women. J. Am. Coll. Nutr. 22, 533-538 https://doi.org/10.1080/07315724.2003.10719332
  5. Garland, H. O. 1992. New experimental data on the relationship between diabetes mellitus and magnesium. Magnes. Res. 5, 193-202
  6. Hans, C. P., D. P. Chaudhary, and D. D. Bansal. 2003. Effect of magnesium supplementation on oxidative stress alloxanic diabetic rats. Magnes. Res. 16, 13-19
  7. Kimata, H., H. Tai, and K. Nakagawa. 2002. Improvement of skin symptoms and mineral imbalance by drinking deep sea water in patients with atopic eczema/dermatitis syndrome (AEDS). Acta. Media 45, 83-84
  8. Lal, J., K. Vasudev, A. K. Kela, and S. K. Jain. 2003. Effect of oral magnesium supplementation on the lipid profile and blood glucose of patients with type 2 diabetes mellitus. J. Assoc. Physicians India 51, 37-42
  9. Lopez-Ridaura, R., W. C. Willett, E. B. Rimm, and S. Liu. 2004. Magnesium intake and risk of type 2 diabetes in men and women. Diabetes Care 27, 134-140 https://doi.org/10.2337/diacare.27.1.134
  10. Mather, H. M., J. A. Nidbet, G. H. Nutyon, G. J. Podyon, J. M. Bland, P. A. Bailey, and T. R. E. Pilkington. 1979. Hypomagnesaemia in diabetes. Clin. Chim. Acta. 95, 235-242 https://doi.org/10.1016/0009-8981(79)90364-4
  11. McCarty, M. F. 2004. Magnesium may mediate the favorable impact of whole grains on insulin sensitivity by acting as a mild calcium antagonist. Medical Hypotheses 64, 619-627 https://doi.org/10.1016/j.mehy.2003.10.034
  12. Paolisso, G. and M. Barbagallo. 1997. Hypertension, diabetes mellitus, and insulin resistance. Am. J. Hypertension 10, 346-355 https://doi.org/10.1016/S0895-7061(96)00342-1
  13. Paolisso, G., A. Scheen, F. D'Onofrio, and P. Lefebvre. 1990. Magnesium and glucose homeostasis. Diabetologia 33, 511-514 https://doi.org/10.1007/BF00404136
  14. Rodriguez-Moran, M. and F. Guerrero-Romero. 2003. Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial. Diabetes Care 26,1147-1152 https://doi.org/10.2337/diacare.26.4.1147
  15. Sheehan, J. P. 1991. Magnesium deficiency and diabetes mellitus. Magnes. Trace Elem. 10, 215-219
  16. Soltani, N., M. Kesgavarz, B. Minaii, F. Mirershadi, S. Z. Asl, and A. R. Dehpour. 2005. Effects of administration of oral magnesium on plasma glucose and pathological changes in the aorta and pancreas of diabetic rats. Clin. Exp. Pharmacol. Physiol. 32, 604-610 https://doi.org/10.1111/j.0305-1870.2005.04238.x
  17. Suzuki, H. 2002. Mystery of Deep Sea Water, pp. 66, Translated by J. Im, ed. by J. Ku. The Herald Business (Naewaynews), Seoul
  18. Wilson, G. L., N. J. Patton, J. M. McCord, D. W. Mullins, and B. T. Mossman. 1984. Mechanism of streptozotocin-induced damages in rat β-cells. Diabetologia 27, 587 https://doi.org/10.1007/BF00276973