Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
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MMP-1 promoter polymorphism in Korean with generalized aggressive periodontitis

  • Oh, Hyong-Suk (Department of Periodontology, School of Dentistry and Dental Science Research Institute, Chonnam National University) ;
  • Kim, Ok-Su (Department of Periodontology, School of Dentistry and Dental Science Research Institute, Chonnam National University) ;
  • Kim, Young-Jun (Department of Periodontology, School of Dentistry and Dental Science Research Institute, Chonnam National University, 2nd stage of BK 21 project, School of Dentistry, Chonnam National University) ;
  • Chung, Hyun-Ju (Department of Periodontology, School of Dentistry and Dental Science Research Institute, Chonnam National University, 2nd stage of BK 21 project, School of Dentistry, Chonnam National University)
  • Published : 2009.08.15
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Abstract

Purpose: The aim of this study was to investigate matrix metalloproteinase 1 (MMP-1) gene polymorphism (1G/2G at -1607 and A/G at -519) in Korean subject and to assess the association between polymorphism and periodontal status. Methods: Forty nine generalized aggressive periodontitis (GAP) patients and 57 periodontally healthy children were recruited and genomic DNA was extracted from buccal swab. The polymorphisms of MMP-1 promoter genes were determined by polymerase chain reaction and restriction fragment length product (PCR-RFLP) method. The distribution of genotype and allele frequency was compared between 2 groups by ${\chi}^2$ test. Results: There was a significant difference in the distribution of genotypes and frequency of alleles between the GAP and reference groups at the position - 519 of MMP-1 gene promoter (P<0.05). Allele G carrier rate was significantly lower in GAP group than that of the reference group (P< 0.001). At the position -1607 of MMP-1 gene promoter, genotype distribution and allele frequency showed no statistically significant difference between the groups. However, in the female group, a significant difference was observed between the groups for the genotype distribution, allele frequency and allele 1G carrier rate (P< 0.05). Conclusions: The DNA polymorphism at the MMP-1 gene promoter might be associated with GAP in Korean.

Keywords

References

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