Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
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Bone regeneration capacity of two different macroporous biphasic calcium materials in rabbit calvarial defect

  • Park, Jung-Chul (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Lim, Hyun-Chang (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Sohn, Joo-Yeon (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Yun, Jeong-Ho (Department of Dentistry, College of Medicine, Kwandong University, Myongji Hospital) ;
  • Jung, Ui-Won (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Kim, Chang-Sung (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Cho, Kyoo-Sung (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Kim, Chong-Kwan (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Choi, Seong-Ho (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University)
  • Published : 2009.08.15
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Abstract

Purpose: Synthetic bone products such as biphasic calcium phosphate (BCP) are mixtures of hydroxyapatite (HA) and ${\beta}$-tricalcium phosphate (${\beta}$- TCP). In periodontal therapies and implant treatments, BCP provides to be a good bone reconstructive material since it has a similar chemical composition to biological bone apatites. The purpose of this study was to compare bone regeneration capacity of two commercially available BCP. Methods: Calvarial defects were prepared in sixteen 9-20 months old New Zealand White male rabbits. BCP with HA and ${\beta}$- TCP (70:30) and BCP with Silicon-substituted hydroxyapatite (Si-HA) and ${\beta}$-TCP (60:40) particles were filled in each defect. Control defects were filled with only blood clots. Animals were sacrificed at 4 and 8 week postoperatively. Histomorphometric analysis was performed. Results: BCP with HAand ${\beta}$- TCP 8 weeks group and BCP with Si-HA and ${\beta}$- TCP 4 and 8 weeks groups showed statistically significant in crease (P <0.05) in augmented area than control group. Newly formed bone area after 4 and 8 weeks was similar among all the groups. Residual materials were slightly more evident in BCP with HA and ${\beta}$- TCP 8 weeks group. Conclusions: Based on histological results, BCP with HA and ${\beta}$- TCP and BCP with Si-HA and ${\beta}$- TCP appears to demonstrate acceptable space maintaining capacity and elicit significant new bone formation when compared to natural bone healing in 4 and 8 week periods.

Keywords

References

  1. Barboza EP. Clinical and histologic evaluation of the demineralized freeze-dried bone membrane used for ridge augmentation. Int J Periodontics Restorative Dent 1999;19:601-607
  2. Daculsi G, Laboux O, Malard O, Weiss P. Current state of the art of biphasic calcium phosphate bioceramics. J Mater Sci Mater Med 2003;14:195-200
  3. Daculsi G, Passuti N, Martin S et al. Macroporous calcium phosphate ceramic for long bone surgery in humans and dogs. Clinical and histological study. J Biomed Mater Res 1990;24:379-396 https://doi.org/10.1002/jbm.820240309
  4. LeGeros RZ, Parsons JR, Daculsi G et al. Significance of the porosity and physical chemistry of calcium phosphate ceramics. Biodegradation-bioresorption. Ann N Y Acad Sci 1988;523:268-271 https://doi.org/10.1111/j.1749-6632.1988.tb38519.x
  5. Levin MP, Getter L, Adrian J, Cutright DE. Healing of periodontal defects with ceramic implants. J Clin Periodontol 1974;1:197-205 https://doi.org/10.1111/j.1600-051X.1974.tb01258.x
  6. Levin MP, Getter L, Cutright DE, Bhaskar SN. Biodegradable ceramic in periodontal defects. Oral Surg Oral Med Oral Pathol 1974;38:344-351 https://doi.org/10.1016/0030-4220(74)90359-4
  7. Yukna RA, Cassingham RJ, Caudill RF et al. Six month evaluation of Calcitite (hydroxyapatite ceramic) in periodontal osseous defects. Int J Periodontics Restorative Dent 1986;6:34-45
  8. Froum SJ, Kushner L, Scopp IW, Stahl SS. Human clinical and histologic responses to Durapatite implants in intraosseous lesions. Case reports. J Periodontol 1982;53:719-725 https://doi.org/10.1902/jop.1982.53.12.719
  9. Moskow BS, Lubarr A. Histological assessment of human periodontal defect after durapatite ceramic implant. Report of a case. J Periodontol 1983;54:455-462 https://doi.org/10.1902/jop.1983.54.8.455
  10. Ellinger RF, Nery EB, Lynch KL. Histological assessment of periodontal osseous defects following implantation of hydroxyapatite and biphasic calcium phosphate ceramics: a case report. Int J Periodontics Restorative Dent 1986;6:22-33
  11. Karabuda C, Ozdemir O, Tosun T, Anil A, Olgac V. Histological and clinical evaluation of 3 different grafting materials for sinus lifting procedure based on 8 cases. J Periodontol 2001;72:1436-1442 https://doi.org/10.1902/jop.2001.72.10.1436
  12. Jarcho M. Calcium phosphate ceramics as hard tissue prosthetics. Clin Orthop Relat Res 1981:259-278
  13. Jarcho M. Biomaterial aspects of calcium phosphates. Properties and applications. Dent Clin North Am 1986;30:25-47
  14. Nery EB, LeGeros RZ, Lynch KL, Lee K. Tissue response to biphasic calcium phosphate ceramic with different ratios of HA/beta TCP in periodontal osseous defects. J Periodontol 1992;63:729-735 https://doi.org/10.1902/jop.1992.63.9.729
  15. Block MS, Kent JN. A comparison of particulate and solid root forms of hydroxylapatite in dog extraction sites. J Oral Maxillofac Surg 1986;44:89-93 https://doi.org/10.1016/0278-2391(86)90187-4
  16. Lee J, Jung U, Kim C, Choi S, Cho K. Maxillary sinus augmentation using macroporous biphasic calcium phosphate (MBCP$^{TM}$) : Three case report with histologic evaluation. J Korean Acad Periodontol 2006;36:567-577 https://doi.org/10.5051/jkape.2006.36.2.567
  17. Daculsi G, LeGeros RZ, NeryE, Lynch K, Kerebel B. Transformation of biphasic calcium phosphate ceramics in vivo: ultrastructural and physicochemical characterization. J Biomed Mater Res 1989;23:883-894 https://doi.org/10.1002/jbm.820230806
  18. Bertoni E, Bigi A, Cojazzi G et al. Nanocrystals of magnesium and fluoride substituted hydroxyapatite. J Inorg Biochem 1998;72:29-35 https://doi.org/10.1016/S0162-0134(98)10058-2
  19. Skrtic D, Antonucci JM, Eanes ED, Brunworth RT. Silicaand zirconia-hybridized amorphous calcium phosphate: effect on transformation to hydroxyapatite. J Biomed Mater Res 2002;59:597-604 https://doi.org/10.1002/jbm.10017
  20. Hollinger JO, Kleinschmidt JC. The critical size defect as an experimental model to test bone repair materials. J Craniofac Surg 1990;1:60-68 https://doi.org/10.1097/00001665-199001000-00011
  21. Marx RE, Carlson ER, Eichstaedt RM et al. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;85:638-646 https://doi.org/10.1016/S1079-2104(98)90029-4
  22. Sandy J, Davies M, Prime S, Farndale R. Signal pathways that transduce growth factor-stimulated mitogenesis in bone cells. Bone 1998;23:17-26 https://doi.org/10.1016/S8756-3282(98)00067-2
  23. Horner A, Bord S, Kemp P, Grainger D, Compston JE. Distribution of platelet-derived growth factor (PDGF) A chain mRNA, protein, and PDGF-alpha receptor in rapidly forming human bone. Bone 1996;19:353-362 https://doi.org/10.1016/S8756-3282(96)00217-7
  24. Lee YJ, Jung SW, Chae GJ, Cho KS, Kim CS. The effect of recombinant human bone morphogenetic protein-2/macroporous biphasic calcium phosphate block system on bone formation in rat calvarial defects. J Korean Acad Periodontol 2007;37:397-407 https://doi.org/10.5051/jkape.2007.37.Suppl.397
  25. Wikesjo UM, Huang YH, Polimeni G, Qahash M. Bone morphogenetic proteins: a realistic alternative to bone grafting for alveolar reconstruction. Oral Maxillofac Surg Clin North Am 2007;19:535-551, vi-vii https://doi.org/10.1016/j.coms.2007.07.004
  26. Klein CP, Driessen AA, de Groot K, van den Hooff A. Biodegradation behavior of various calcium phosphate materials in bone tissue. J Biomed Mater Res 1983;17:769-784 https://doi.org/10.1002/jbm.820170505
  27. Kwon S, Jun Y, Hong S. Synthesis and dissolution behavior of $\beta$-TCP and HA/$\beta$-TCP composite powders J. Euro. Ceram. Soc. 2003;23:1039-1045 https://doi.org/10.1016/S0955-2219(02)00263-7
  28. Gauthier O, Bouler JM, Aguado E, Pilet P, Daculsi G. Macroporous biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth. Biomaterials 1998;19:133-139 https://doi.org/10.1016/S0142-9612(97)00180-4
  29. LeGeros RZ. Calcium phosphate materials in restorative dentistry: a review. Adv Dent Res 1988;2:164-180 https://doi.org/10.1177/08959374880020011101
  30. Metsger DS, Driskell TD, Paulsrud JR. Tricalcium phosphate ceramic--a resorbable bone implant: review and current status. J Am Dent Assoc 1982;105:1035-1038 https://doi.org/10.14219/jada.archive.1982.0408
  31. Um YJ, Hong JY, Kim ST et al. Bone formation of newly developed biphasic calcium phosphate in rabbit calvarial defect model : A pilot study. J Korean Acad Periodontol 2008;38:163-170 https://doi.org/10.5051/jkape.2008.38.2.163