Environmental Analysis Health and Toxicology

환경독성보건학회 (The Korean Society of Environmental Health and Toxicology)
권호 표지

백작약 열수추출물의 피부노화 억제 효과(I) -염증 및 피부장벽 손상 완화 효과를 중심으로-

Inhibitory Effects of Peonia japonica Water Extract on Skin Aging (I) - Focussed on Alleviative Effects of Inflammation and Skin Barrier Damage -

  • 권미화 (국립독성과학원 독성병리과) ;
  • 민경진 (계명대학교 대학원 공중보건학과) ;
  • 김영철 (계명대학교 대학원 공중보건학과)
  • Kwon, Mi-Hwa (Department of Toxicolopathology, National Institute of Toxicological Research) ;
  • Min, Kyung-Jin (Department of Public Health, Keimyung University) ;
  • Kim, Young-Chul (Department of Public Health, Keimyung University)
  • 발행 : 2009.06.30
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초록

To investigate the alleviative effects of Peonia japonica water extract(PJWE) on inflammation and skin barrier damage, both the irradiation of UVB and the application of squalene monohydroperoxide (Sq-OOH) to the backs of hairless mice were performed for 4 weeks. And at the same time experimental materials were applied topically. The skin erythema indices for the positive control (PC, 0.01% retinoic acid) and experimental (E, PJWE) groups were lower than that of the control (C) group. Whereas both the lipid and water capacities for the PC and E groups were higher than those of the C group. Epidermis and dermis of the C group were remarkably thickened in comparison with the PC and E groups. Relatively much less number of inflammatory cells, including lymphocytes, neutrophils and macrophages were found in dermis of the PC and E groups compared with the C group. Lipid lamellae of the C group were broken severely showing an irregular arrangement and lipid content was much reduced. Whereas those of the PC and E groups were almost intact with a regular arrangement, which were similar to that of the N group. Taken the results all together, it was confirmed that PJWE could be effective natural herbal material for the alleviation of inflammation and skin barrier damage in hairless mice skin which were induced by UVB and Sq-OOH.

키워드

참고문헌

  1. 강병철, 이나래, 권은아, 강창길, 정희원, 박상영, 이상구, 이국현, 성명훈, 정진호. 레티놀 크림 I∙vII의 피부자극성 및 안점막자극성에 관한 연구, 한국실험동물학회지 2002; 18(4): 177-183
  2. 김주덕, 엄정녀. 한방 화장품 구매행동에 관한 실증적 연구, 대한화장품학회지 2004; 30(1): 93-102
  3. 최현주, 한승경, 박윤기. 각종 자외선차단제품의 자외선 B에 의한 피부 손상에 대한 예방효과, 대한피부과학회지 1995; 33(1): 8-18
  4. Aimi N, Inaba M, Watanabe M and Shibata S. Chemical studies on the oriental plant drugs. XXIII. Paeoniflorin, a glucoside of Chinese paeony root, Tetrahedron 1969; 25(9): 1825-1838 https://doi.org/10.1016/S0040-4020(01)82804-0
  5. Chiba K, Kawakami K, Sone T and Onoue M. Characteristics of skin wrinkling and dermal changes induced by repeated application of squalene monohydroperoxide to hairless mouse skin, Skin Pharmacol Appl Skin Physiol 2003; 16(4): 242-251 https://doi.org/10.1159/000070847
  6. Chiba K, Sone T, Kawakami K and Onoue M. Skin roughness and wrinkle formation induced by repeated application of squalene monohydroperoxide to the hairless mouse, Exp Dermatol 1999; 8(6): 471-479 https://doi.org/10.1111/j.1600-0625.1999.tb00305.x
  7. Fisher GJ, Esmann J, Griffiths CEM, Talwar HS, Duell EA, Hammerberg C, Elder JT, Karabin GD, Nickoloff BJ, Cooper KD and Voorhees JJ. Cellular, immunologic and biochemical characterization of topical retinoic acidtreated human skin, J Invest Dermatol 1991; 96(5): 699-707 https://doi.org/10.1111/1523-1747.ep12470632
  8. Kligman LH and Kligman AM. The nature of photoageing: its prevention and repair, Photodermatol 1986; 3(4): 215-227
  9. Kligman LH, Crosby MJ and Higley H. The UVB-irradiated hairless mouse as a model for the evaluation of injectable collagen implants, J Dermatol Treat 1993; 4(1): 27-31 https://doi.org/10.3109/09546639309088233
  10. Park HR, Jung UJ, Jeoung IY, Yee ST and Jo SK. Inhibition of tumor growth through macrophage activation by polysaccharide fraction from Peonia japonica, J Korean Soc Food Sci Nutr 2003; 32(1): 149-154 https://doi.org/10.3746/jkfn.2003.32.1.149
  11. Pathak MA. Formation of thymine dimers in mammalian skin by ultraviolet radiation in vivo, Photochem Photobiol 1972; 15(2): 177-185 https://doi.org/10.1111/j.1751-1097.1972.tb06237.x
  12. Weiss JS, Ellis CN, Headington JT and Voorhees JJ. Topical tretinoin in the treatment of aging skin, J Am Acad Dermatol 1988; 19(1): 169-175 https://doi.org/10.1016/S0190-9622(88)70161-9