Environmental Analysis Health and Toxicology

The Korean Society of Environmental Health and Toxicology (환경독성보건학회)
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A Study of Mammalian Erythrocyte Micronucleus Induction with Aluminum Oxide, Calcium Oxide, Sodium Tetraborate

Aluminum oxide, calcium oxide, sodium tetraborate 처리에 의한 설치류 골수세포의 소핵유발 연구

  • Rim, Kyung-Taek (Chemical Safety&Health Center, Occupational Safety&Health Research Institute, Korea Occupational Safety&Health Agency) ;
  • Kim, Soo-Jin (Chemical Safety&Health Center, Occupational Safety&Health Research Institute, Korea Occupational Safety&Health Agency) ;
  • Kim, Jong-Kyu (Chemical Safety&Health Center, Occupational Safety&Health Research Institute, Korea Occupational Safety&Health Agency) ;
  • Kang, Min-Gu (Chemical Safety&Health Center, Occupational Safety&Health Research Institute, Korea Occupational Safety&Health Agency) ;
  • Kim, Hyeon-Yeong (Chemical Safety&Health Center, Occupational Safety&Health Research Institute, Korea Occupational Safety&Health Agency) ;
  • Yang, Jeong-Sun (Chemical Safety&Health Center, Occupational Safety&Health Research Institute, Korea Occupational Safety&Health Agency)
  • 임경택 (한국산업안전보건공단 산업안전보건연구원 화학물질안전보건센터) ;
  • 김수진 (한국산업안전보건공단 산업안전보건연구원 화학물질안전보건센터) ;
  • 김종규 (한국산업안전보건공단 산업안전보건연구원 화학물질안전보건센터) ;
  • 강민구 (한국산업안전보건공단 산업안전보건연구원 화학물질안전보건센터) ;
  • 김현영 (한국산업안전보건공단 산업안전보건연구원 화학물질안전보건센터) ;
  • 양정선 (한국산업안전보건공단 산업안전보건연구원 화학물질안전보건센터)
  • Published : 2009.06.30
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Abstract

We have investigated the genotoxicity of 3 chemicals, aluminum oxide, calcium oxide, sodium tetraborate using mammalian erythrocyte with micronucleus induction. It was performed using 9 week male ICR mice. At 24 hours after treatment with 3 chemicals with oral route, mice were sacrificed and bone marrow cells were prepared for smear slides. As a result of counting the micronucleated polychromatic erythrocyte (MNPCE) of 2,000 polychromatic erythrocytes (PCE), all treatment groups did not show statistically significant increase than negative control group. And there was no clinical sign related with injection of the 3 chemicals. It was concluded that the 3 chemicals did not induce micronucleus in the bone marrow cells of ICR mice, and these results indicate that the 3 chemicals have no mutagenic potential under the condition in each studies.

Keywords

References

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