DOI QR코드

DOI QR Code

Preparation of Chitosan-coated Magnetite Nanoparticles by Sonochemical Method for MRI Contrast Agent

  • Cho, Jun-Hee (Quantum Optics Division, Korea Atomic Energy Research Institute) ;
  • Ko, Sang-Gil (Environment & Resources Research Center, Korea Research Institute of Chemical Technology) ;
  • Ahn, Yang-Kyu (Department of Chemistry, Konyang University) ;
  • Choi, Eun-Jung (Department of Opthalmic Optics, Konyang University)
  • 발행 : 2009.09.30

초록

Magnetic nanoparticles were synthesized by using the sonochemical method with oleic acid as a surfactant. The average size of the magnetite nanoparticles was controlled by varying the ratio R=[$H_2O$]/[surfactant] in the range of 2 to 9 nm. To prepare chitosan-coated magnetite nanoparticles, chitosan solution was added to a magnetite colloid suspension under ultrasonication at room temperature for 20 min. The chitosan-coated magnetite nanoparticles were characterized by several techniques. Atomic force microscopy (AFM) was used to image the chitosan-coated nanoparticles. Magnetic hysteresis measurement was performed by using a superconducting quantum interference device (SQUID) magnetometer to investigate the magnetic properties of the magnetite nanoparticles and the chitosan-coated magnetite nanoparticles. The SQUID measurements revealed the superparamagnetism of both nanoparticles. The T1- and T2-weighted MR images of these chitosan-coated magnetite colloidal suspensions were obtained with a 4.7 T magnetic resonance imaging (MRI) system. The chitosancoated magnetite colloidal suspensions exhibited enhanced MRI contrasts in vitro.

키워드

참고문헌

  1. X. M. Lin and C. S. Samia, J. Magn. Magn. Mater. 305, 100 (2006) https://doi.org/10.1016/j.jmmm.2005.11.042
  2. A. Ito, M. Shinkai, H. Honda, and T. Kobayashi, J. Biosci. Bioeng. 100(6), 1 (2005) https://doi.org/10.1263/jbb.100.1
  3. Y. Deng, L. Wang, W. Yang, S. Fu, and A Ela.ýssari, J. Magn. Magn. Mater. 257, 69 (2003) https://doi.org/10.1016/S0304-8853(02)00987-3
  4. Yong Jae Suh, Dae Sup Kil, Kang Sup Chung, Hyo Sook Lee, and Huiping Shao, J. Magnetics 13, 106 (2008) https://doi.org/10.4283/JMAG.2008.13.3.106
  5. A. K. Gupta and M. Gupta, Biomater. 26, 3995 (2005) https://doi.org/10.1016/j.biomaterials.2004.10.012
  6. E. H. Kim, H. S. Lee, B. K. Kwak, and B. K. Kim, J. Magn. Magn. Mater. 289, 328 (2005) https://doi.org/10.1016/j.jmmm.2004.11.093
  7. M.C. Bautista, O. B. Miguel, X. Zhao, M. P. Morales, T G. Carreno, R. P. Alejo, J. R. Cabello, and S. V. Verdaguer, Institute of Physics Publishing; Nanotechnology, vol 15, pp. S154-S159 (2004) https://doi.org/10.1088/0957-4484/15/4/008
  8. S. Baxter, S. Zivanovic, and J. Weiss, Food Hydrocolloids 19, 821 (2005) https://doi.org/10.1016/j.foodhyd.2004.11.002
  9. Y. C. Chang and D. H. Chen, J. Colloid and Interface Science 283, 446 (2005) https://doi.org/10.1016/j.jcis.2004.09.010