Transient Biclonal Gammopathy Associated With Tsutsugamushi Meningitis

쯔쯔가무시 뇌막염과 연관된 이크론성 감마글로불린병증

  • Park, Hyun-Young (Department of Neurology, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science) ;
  • Kim, Soo-Seong (Department of Neurology, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science) ;
  • Lee, Hak-Seung (Department of Neurology, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science) ;
  • Chang, Hyuk (Department of Neurology, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science) ;
  • Cho, Kwang-Ho (Department of Neurology, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science) ;
  • Kim, Yo-Sik (Department of Neurology, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science)
  • 박현영 (원광대학교 의과대학 신경과학교실, 원광의과학연구소) ;
  • 김수성 (원광대학교 의과대학 신경과학교실, 원광의과학연구소) ;
  • 이학승 (원광대학교 의과대학 신경과학교실, 원광의과학연구소) ;
  • 장혁 (원광대학교 의과대학 신경과학교실, 원광의과학연구소) ;
  • 조광호 (원광대학교 의과대학 신경과학교실, 원광의과학연구소) ;
  • 김요식 (원광대학교 의과대학 신경과학교실, 원광의과학연구소)
  • Received : 2009.04.06
  • Accepted : 2009.09.21
  • Published : 2009.12.30

Abstract

Biclonal gammopathy is characterized by the presence of two different monoclonal immunoglobulins, and the clinical findings of biclonal gammopathy are similar to those of monoclonal gammopathy. An association between biclonal gammopathy and tsutsugamushi meningitis has not been reported previously. Here, we report a case of a 55-year-old man presented with fever and decreased mentality. A cerebrospinal fluid (CSF) test and an indirect immunofluorescent antibody test for Orientia tsutsugamushi revealed tsutsugamushi meningitis. CSF and serum immunofixation electrophoresis revealed biclonal gammopathy (IgG-${\kappa}$, IgG-${\lambda}$). His symptoms improved after antibiotics treatment, and serum biclonal gammopathy completely disappeared.

Keywords

References

  1. Seong SY, Choi MS, Kim IS. Orientia tsutsugamushi infection: overview and immune responses. Microbes Infect 2001;3:11-21. https://doi.org/10.1016/S1286-4579(00)01352-6
  2. Silpapojakul K, Ukkachoke C, Krisanapan S, Silpapojakul K. Rickettsial meningitis and encephalitis. Arch Intern Med 1991;151:1753-1757. https://doi.org/10.1001/archinte.151.9.1753
  3. Pai H, Sohn S, Seong Y, Kee S, Chang WH, Choe KW. Central nervous system involvement in patients with scrub typhus. Clin Infect Dis 1997;24:436-440. https://doi.org/10.1093/clinids/24.3.436
  4. Kim IG, Lee SC, Kim JW, Seo KS, Park HB, Lee ST, et al. Two Cases of Tsutsugamushi Meningitis. J Korean Neurol Assoc 2000;18:642-645.
  5. Krause R, Auner HW, Daxbock F, Mulabecirovic A, Krejs GJ, Wenisch C, et al. Monoclonal and biclonal gammopathy in two patients infected with Bartonella henselae. Ann Hematol 2003;82:455-457. https://doi.org/10.1007/s00277-003-0675-4
  6. Ikeda M, Yoshida S, Tsukagoshi H. $Interferon-{\gamma}$ in cerebrospinal fluid without pleocytosis in scrub typhus. J of the Neurological Sciences 1992;109:61-63. https://doi.org/10.1016/0022-510X(92)90094-2
  7. Chung DR, Lee YS, Lee SS. Kinetics of inflammatory cytokines in patients with scrub typhus receiving doxycycline treatment. J Infect 2008;56:44-50. https://doi.org/10.1016/j.jinf.2007.09.009
  8. Seve P, Turner R, Stankovic K, Perard L, Broussolle C. Transient monoclonal gammopathy in a patient with Bartonella quintana endocarditis. Am J Hematol 2006;81:115-117. https://doi.org/10.1002/ajh.20499
  9. Amara S, Dezube BJ, Cooley TP, Pantanowitz L, Aboulafia DM. HIV-associated monoclonal gammopathy: a retrospective analysis of 25 patients. Clin Infect Dis 2006;43:1198-1205. https://doi.org/10.1086/508351
  10. Malik AA, Ganti AK, Potti A, Levitt R, Hanley F. Role of Helicobacter pylori infection in the incidence and clinical course of monoclonal gammopathy of undetermined significance. Am J Gastroenterol 2002;97:1371-1374. https://doi.org/10.1111/j.1572-0241.2002.05668.x