Journal of Oral Medicine and Pain

Korean Academy of Orofacial Pain and Oral Medicine (대한안면통증구강내과학회)
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Antibacterial Activity of Artemisa Capillaris THUNB on Oral Bacteria

인진쑥의 구강세균에 대한 항균작용

  • Chae, Gyu-Chang (Department of Oral Medicine, School of Dentistry, Kyung Hee University) ;
  • Auh, Q-Schick (Department of Oral Medicine, School of Dentistry, Kyung Hee University) ;
  • Chun, Yang-Hyun (Department of Oral Medicine, School of Dentistry, Kyung Hee University) ;
  • Hong, Jung-Pyo (Department of Oral Medicine, School of Dentistry, Kyung Hee University)
  • 채규창 (경희대학교 치의학전문대학원 구강내과학교실) ;
  • 어규식 (경희대학교 치의학전문대학원 구강내과학교실) ;
  • 전양현 (경희대학교 치의학전문대학원 구강내과학교실) ;
  • 홍정표 (경희대학교 치의학전문대학원 구강내과학교실)
  • Published : 2009.06.30
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Abstract

Recently it is very interesting that the plant extracts use to prevent or treat the oral diseases. The present study was performed to observe the antibacterial effect on S. gordonii Challis, S. gordoii G9B, S. mutans GS5, S. sobriuns 6715, E. faecalis ATCC 4083, A. actinomycetem Y4, P. gingivalis A7A1-28, P. gingivalis W83, Pr. intermedia ATCC 25611, F. nucleatum KTCT 2488, C. albicans ATCC 18804 of Artemisa capillaris THUNB employing the viable cell counts. The results were as follows: 1. Minimum inhibitory concentration(MIC) and Minimum bactericidal concentration(MBC) of extracts of Artemisa capillaris THUNB for P. gingivalis A7A1-28, P. gingivalis W83, and Pr. intermedia ATCC 25611, which are the pathologic bacteria of periodontal diseases, was observed under 2%. 2. MIC of extracts of Artemisa capillaris THUNB for P. gingivalis A7A1-28 was determined to be 1.2% and MBC was determined to be 2.0% respectively. 3. MIC of extracts of Artemisa capillaris THUNB for P. gingivalis W83 was determined to be 1.4% and MBC was determined to be 2.0% respectively. 4. MIC of extracts of Artemisa capillaris THUNB for Pr. intermedia ATCC 25611 was determined to be 1.2% and MBC was determined to be 2.0% respectively. The overall results indicate that Artemisa capillaris THUNB used for this study has a strong antibacterial activity against P. gingivalis A7A1-28, P. gingivalis W83, and Pr. intermedia ATCC 25611, which are the periodontopathic bacteria. Therefore, the extracts of Artemisa capillaris THUNB can be used as a candidate for prevention and therapeutic agent against periodontal diseases.

천연 식물 추출물을 구강 질환에 활용하는 방안을 모색하기 위하여, 본 연구는 인진쑥에서 추출한 쑥추출액을 치의학분야에 활용하고자 S. gordonii Challis, S. gordoii G9B, S. mutans GS5, S. sobriuns 6715, E. faecalis ATCC 4083, A. actinomycetem Y4, P. gingivalis A7A1-28, P. gingivalis W83, Pr. intermedia ATCC 25611, F. nucleatum KTCT 2488, C. albicans ATCC 18804에 대한 항균효과를 미생물학적으로 실험하여, 생균수 검사를 통해 다음과 같은 결과를 얻을 수 있었다. 1. 인진쑥추출액에 의한 최소억제농도(minimum inhibitory concentration; MIC)와 최소살균농도(minimum bactericidal concentration; MBC)가 모두 쑥추출액 농도 2.0%이하에서 관찰된 세균은 치주질환 원인균인 P. gingivalis A7A1-28와 P. gingivalis W83, Pr. intermedia ATCC 25611로 나타났다. 2. P. gingivalis A7A1-28의 MIC는 쑥추출액 농도 1.2%, MBC는 2.0%로 관찰되었다. 3. P. gingivalis W83의 MIC는 쑥추출액 농도 1.4%, MBC는 2.0%로 관찰되었다. 4. Pr. intermedia ATCC 25611의 MIC는 쑥추출액 농도 1.2%, MBC는 2.0%로 관찰되었다. 천연 자연물질인 인진쑥이 구강질환을 일으키는 대표적인 균주에 대한 효과를 연구한 본 실험의 결과, 인진쑥은 구강 세균, 특히 P. gingivalis A7A1-28와 P. gingivalis W83, Pr. intermedia ATCC 25611에 대한 항균효과가 있음이 증명되었다. 따라서 이 천연물질이 부작용이 없는 한계 내에서 사용된다면, 구강질환자의 구강 환경 개선을 위한 치약, 구강세척제 등의 구강용품들을 통해 임상에 적극적으로 사용될 수 있을 것으로 생각된다.

Keywords

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