Macromolecular Research

The Polymer Society of Korea (한국고분자학회)
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Compatibility of Diazepam with Polypropylene Multilayer Infusion Container

  • Noh, Dong-Il (Department of Biomedical Science, Medical College of Catholic University) ;
  • Park, Kyu-Nam (Institute of Cell and Tissue Engineering, Medical College of Catholic University) ;
  • Chun, Heung-Jae (Department of Biomedical Science, Medical College of Catholic University) ;
  • Park, Chong-Won (Department of Internal Medicine, Medical College of Catholic University) ;
  • Jang, Ju-Woong (Research Institute of Biomedical Engineering, Korea Bone Bank Co. Ltd.) ;
  • Ahn, Yun-Gyong (Hazardous Substance Research Team, Korea Basic Science Institute)
  • Published : 2009.07.25
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Abstract

Techflex$^{(R)}$, a polypropylene-lined, multilayer infusion bag, was studied for its compatibility with diazepam, in comparison to the conventional infusion bag, Safeflex$^{(R)}$, which is comprised of poly(vinyl chloride) (PVC). Diazepam was diluted in 0.9% sodium chloride isotonic solution and stored in the infusion bags for 24 h. To evaluate the sorption of diazepam into the infusion bags during storage, the concentration of the drug remaining in the bag was measured using gas chromatography-mass spectroscopy. The PVC bags exhibited a marked sorption of diazepam, with a drug loss reaching up to 90% of the initial concentration after 24 h of contact, whereas Techflex$^{(R)}$ inhibited the drug sorption, showing approximately 10%, under the same conditions. The differences in the sorption behaviors of the bags are discussed in terms of solubility parameters and crystallinities of the polymers.

Keywords

References

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