Investigative Magnetic Resonance Imaging

Korean Society of Magnetic Resonance in Medicine (대한자기공명의과학회)
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Effects of Various Intracranial Volume Measurements on Hippocampal Volumetry and Modulated Voxel-based Morphometry

두개강의 용적측정법이 해마의 용적측정술과 화소기반 형태계측술에 미치는 영향

  • Tae, Woo-Suk (Neuroscience Research Institute, Kangwon National University College of Medicine) ;
  • Kim, Sam-Soo (Neuroscience Research Institute, Kangwon National University College of Medicine) ;
  • Lee, Kang-Uk (Neuroscience Research Institute, Kangwon National University College of Medicine) ;
  • Nam, Eui-Cheol (Neuroscience Research Institute, Kangwon National University College of Medicine)
  • 태우석 (뇌신경연구소, 국립강원대학교 의학전문대학원) ;
  • 김삼수 (뇌신경연구소, 국립강원대학교 의학전문대학원) ;
  • 이강욱 (뇌신경연구소, 국립강원대학교 의학전문대학원) ;
  • 남의철 (뇌신경연구소, 국립강원대학교 의학전문대학원)
  • Published : 2009.06.30
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Abstract

Purpose : To investigate the effects of various intracranial volume (ICV) measurement methods on the sensitivity of hippocampal volumetry and modulated voxel-based morphometry (mVBM) in female patients with major depressive disorder (MDD). Materials and Methods : T1 magnetic resonance imaging (MRI) data for 41 female subjects (21 MDD patients, 20 normal subjects) were analyzed. Hippocampal volumes were measured manually, and ICV was measured manually and automatically using the FreeSurfer package. Gray and white matter volumes were measured separately. Results : Manual ICV normalization provided the greatest sensitivity in hippocampal volumetry and mVBM, followed by FreeSurfer ICV, GWMV, and GMV. Manual and FreeSurfer ICVs were similar in normal subjects (p = 0.696), but distinct in MDD patients (p = 0.000002). Manual ICV-corrected total gray matter volume (p = 0.0015) and Manual ICV-corrected bilateral hippocampal volumes (right, p = 0.014; left, p = 0.004) were decreased significantly in MDD patients, but the differences of hippocampal volumes corrected by FreeSurfer ICV, GWMV, or GMV were not significant between two groups (p > 0.05). Only manual ICV-corrected mVBM analysis was significant after correction for multiple comparisons. Conclusion : The method of ICV measurement greatly affects the sensitivity of hippocampal volumetry and mVBM. Manual ICV normalization showed the ability to detect differences between women with and without MDD for both methods.

배경: 두개강내 용적에 대한 수동과 자동 측정법이 여성 주요 우울증 환자의 해마의 용적측정술과 modulated voxel-based morphometry (mVBM)의 결과에 미치는 영향을 알아보고자 한다. 방법: 21명의 여성 주요 우울증 환자와 성별, 나이의 분포가 비슷한 20명의 여성 정상인을 연구대상에 포함시켰다. 해마와 두개강내 용적은 수동으로 측정하였고, FreeSurfer 프로그램을 이용하여 두개강내 용적을 자동으로 측정하였다. 또한 회색질과 백색질의 부피도 SPM을 이용하여 자동으로 측정하였다. 결과: 수동으로 측정한 두개강의 용적을 통제변인으로 하여 분석한 통계분석의 결과가 FreeSurfer에 의해 측정된 두개강내 용적이나 뇌실질의 용적을 통제변인으로 한 통계분석의 결과보다 우울증 환자의 해마부피 감소와 mVBM 분석의 국조적 부피감소를 보다 민감하게 보여주었다. 수동적인 방법과 FreeSurfer에 의해 측정된 두개강내 용적은 정상인에서는 차이가 없었지만 (p = 0.696), 우울증 환자의 두개강 부피는 FreeSurfer를 이용해 측정한 두 개강의 부피가 더 작았다 (p = 0.000002). 우울증 환자의 전체 회색질의 부피는 수동으로 측정한 두개강의 용적을 통제변인으로 적용하였을 때 정상인의 회색질의 부피보다 작았고 (p = 0.000002), 해마의 부피도 수동으로 측정한 두 개 강의 부피를 통제변인으로 통계처리를 했을 때는 우울증환자의 해마가 뚜렷한 위축을 보였지만 (오른쪽, p = 0.014; 왼쪽, p = 0.004), 다른 측정법을 통제변인으로 했을 때는 유의하지 않았다 (p > 0.05). mVBM 분석에서는 수동으로 측정한 두개강의 부피를 통제변인으로 사용했을 때만 다중비교교정 후에 유의한 결과를 보였다 (FDR p < 0.05). 결론: 수동적인 방법으로 측정한 두개강의 용적이 FreeSurfer에 의해 자동으로 측정된 두개강의 용적이나 뇌실질의 부피보다 해마용적측정술과 mVBM 의 결과에 있어서 더 효율적으로 우울증이 있는 그룹과 없는 그룹의 차이를 보여주는 것에 민감한 결과를 보였다.

Keywords

References

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