The Journal of Korean Physical Therapy

The Korean Society of Physical Therapy (대한물리치료학회)
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Influence of Microcurrent Therapy in Interleukin-1 Expression in Rhueumatoid Arthritis Rats

미세전류치료가 류마티스 관절염 유발 흰쥐의 Interleukin-1 발현에 미치는 영향

  • Lee, Hyun-Min (Department of Physical Therapy, College of Public Health and Natural Science, International University of Korea) ;
  • Chae, Yun-Won (Department of Physical Therapy, Gwangju Health College University)
  • 이현민 (한국국제대학교 보건자연과학대학 물리치료학과) ;
  • 채윤원 (광주보건대학 물리치료과)
  • Received : 2009.04.27
  • Accepted : 2009.06.16
  • Published : 2009.06.25
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Abstract

Purpose: Electrical stimulation is one of several treatments recommended for RA patients. Electrical stimulation of RA patients, reduces pain, or facilitates joint motion prior to exercises. However, there is still limited evidence on the efficacy of electrical stimulation and thus any conclusions drawn about this method remain controversial. Recently, Microcurrent Electrical Neuromuscular Stimulation (MENS) has received significant attention as a potential method of electrical stimulation. In this study, we investigated the effect of microcurrent treatment in rheumatoid arthritis rat. Methods: Subjects were allocated either to the control group or experimental group, which was subject to microcurrent stimulation. Interleukin-1 expression in the metatarsophlangeal joint and the oedema index in the ankle were used for classification and subsequent evaluation of pathology. Subjects were assessed at 1, 7 and 14 days after inducing rheumatoid arthritis through adjuvant injection. Thirty-six subjects, 18 in each group, were used in this study. Statistical analysis was performed by calculating the differences between the two groups and between each interval assessment. Categorical variables were compared between the two groups with the paired-T test. The one-way ANOVA test was performed to assess changes in ordinal variables. Results: Baseline characteristics were similar in both groups. Statistically significant differences were found between the two groups. The biological marker of pro-inflammatory cytokine and oedema index were decreased in response to this treatment. Conclusion: These data show that treatment of rheumatoid arthritis with a microcurrent stimulation device reduced the oedema index and pro-inflammatory cytokine IL-1.

Keywords

References

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