The Effect of Hyulbuchuko-tang on a Case with Deep Vein Thrombosis (DVT) and Intracranial Hemorrhage (ICH)

뇌출혈로 항응고제 사용이 불가능한 심부 정맥혈전증에 대한 혈부축어탕 치험례

  • Kang, Ji-Suck (Dept. of Internal medicine, College of Oriental Medicine, Kyung-hee University) ;
  • Park, Sung-Hwan (Dept. of Internal medicine, College of Oriental Medicine, Kyung-hee University) ;
  • Song, Moon-Koo (Dept. of Internal medicine, College of Oriental Medicine, Kyung-hee University) ;
  • Ahn, Young-Min (Dept. of Internal medicine, College of Oriental Medicine, Kyung-hee University) ;
  • Ahn, Se-Young (Dept. of Internal medicine, College of Oriental Medicine, Kyung-hee University) ;
  • Lee, Byung-Cheol (Dept. of Internal medicine, College of Oriental Medicine, Kyung-hee University)
  • 강지석 (경희대학교 한의과대학 신계내과학교실) ;
  • 박성환 (경희대학교 한의과대학 신계내과학교실) ;
  • 송문구 (경희대학교 한의과대학 신계내과학교실) ;
  • 안영민 (경희대학교 한의과대학 신계내과학교실) ;
  • 안세영 (경희대학교 한의과대학 신계내과학교실) ;
  • 이병철 (경희대학교 한의과대학 신계내과학교실)
  • Published : 2009.06.30

Abstract

Objectives: Deep vein thrombosis (DVT) is a common complication among stroke patients. The implication of DVT progressing into a fatal pulmonary embolism is one of the main reasons treatment cannot be delayed. However, when there is a contradiction for anticoagulants, such intracranial hemorrhage (ICH), it is difficult to determine the course of treatment. Our team reports a case with both acute DVT and ICH who improved with herbal medicine Hyulbuchuko-tang. Methods : A patient with a variety of thrombosis risk factors (atrial fibrillation, DVT, Cb-inf with intracranial hemorrhage due to thrombolytic complications) showed classic symptoms of DVT (pain, edema, discoloration), disorientation and chest discomfort. The patient was administered Hyulbuchuko-tang three times a day for 24 days without any anticoagulants. Conservative therapy including elastic stocking and leg elevation was co-administered. Laboratory tests and extremity vascular Doppler sonography were carried out 3 times during the treatment period. Results : After our treatment period, both popliteal vein DVT and calf vein DVT were not discovered by sonography, and thrombosis derived factors (eg. D-dimer, fibrinogen) decreased. There was no sign of edema or discoloration after treatment, and the patient no longer complained of leg pain, disorientation or chest discomfort. Conclusion : From these results, we suggest that there is a positive effect of Hyulbuchuko-tang on DVT. Hyulbuchuko-tang should be considered as a treatment option when western medical procedures are unavailable.

Keywords

References

  1. 김동익. 정맥학. 서울: 의학문화사;2007, p. 91-114.
  2. Brandstater ME, Roth EJ, Siebens HC. Venous thromboembolism in Stroke: literature review and implications for clinical practice. Arch Phys Med Rehabil. 1992;73:S379-91.
  3. Ogata T, Yasaka M, Wakugawa Y, Inoue T, Ibayashi S, Okada Y. Deep venous thrombosis after acute intracerbral hemorrhage. J Neurol Sci. 2008;272(1-2):83-6. https://doi.org/10.1016/j.jns.2008.04.032
  4. Kelly J, Rudd A, Lewis R, Hunt BJ. Venous thromboembolism after acute Stroke. Stroke. 2001;32;262-7. https://doi.org/10.1161/01.STR.32.1.262
  5. 민부기, 김세종, 강준혁, 박장우, 윤일지, 오민석. 방광루술후 발생한 심부정맥혈전증 환자 1례에 대한 임상적 고찰. 대한한의정보학회지. 2005;11(2):14-22.
  6. 김태환, 김현호, 홍솔이, 임은철. 심부혈전증으로 인한 소양인 하지부종 치험 1례. 사상체질의학회지. 2006;18(3):202-9.
  7. 설재욱, 신미숙, 최진봉. 심부정맥혈전증으로 의심되는 환자 1례에 대한 임상적 고찰. 한방재활의학과학회지. 2004;14(2):137-45.
  8. 허준. 동의보감. 서울: 동의보감 출판사;2005, p. 785-95, 1421-2, 1097, 97.
  9. Chua K, Kong KH, Chan SP. Prevalence and risk factors of asymptomatic lower extremity deep venous thrombosis in Asian neurorehabilitation admissions in Singapore. Arch Phys Med Rehabil. 2008;89(12):2316-23. https://doi.org/10.1016/j.apmr.2008.05.025
  10. DeSilva DA, Pey HB, Wong MC, CHang HM, CHen CPLH. Deep vein thrombosis following ischaemic Stroke among Asians. Cerebrovasc Dis 2006;22:245-50. https://doi.org/10.1159/000094011
  11. Qaseem A, Snow V, Barry P, Hornbake ER, Rodnick JE, Tobolic T, Ireland B, et al. Current diagnosis of venous thromboembolism in primary care: a clinical practice guideline from the American Academy of Family Physicians and the American College of Physicians. Ann Fam Med. 2007;5(1):57-62. https://doi.org/10.1370/afm.667
  12. Philbrick JT, Becker DM. Calf deep venous thrombosis. A wolf in sheep's clothing?. Arch Intern Med. 1988;148(10):2131-8. https://doi.org/10.1001/archinte.148.10.2131
  13. International Stroke Trial Collaborative Group. The International Stroke Trial(IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic Stroke. International Stroke Trial Collaborative Group. Lancet. 1997;349(9065):1569-81. https://doi.org/10.1016/S0140-6736(97)04011-7
  14. Warlow C, Ogston D, Douglas AS. Deep venous thrombosis of the legs after Strokes: Part 2-Natural history. Br Med J;1(6019):1178-81.
  15. Wijdicks EF, Scott JP. Pulmonary embolism associated with acute Stroke. Mayo Clin Proc. 1997;7(24):297-300.
  16. White RH, Zhou H, Kim J, Romano PS. A population -based study of the effectiveness of inferior vena cava filter use among patients with venous thromboembolism. Arch Intern Med. 2000;160 (13):2033-41. https://doi.org/10.1001/archinte.160.13.2033
  17. Heit JA, Silverstein MD, Mohr DN, Petterson TM, O'Fallon WM, Melton LJ 3rd. Predictors of Survival After Deep Vein Thrombosis and Pulmonary Embolism: A Population-Based, Cohort Study. Arch Intern Med. 1999;159(5):445-53. https://doi.org/10.1001/archinte.159.5.445
  18. Barritt DW, Jordan SC. Anticoagulant drugs in the treatment of pulmonary embolism, a controlled trial. Lancet. 1960;1(7138):1309-12.
  19. Doyle DJ, Turpie AG, Hirsh J, et al: Adjusted subcutaneous heparin or continuous intravenous heparin in patients with acute deep vein thrombosis. A randomized trial. Ann Intern Med 1987;107:441
  20. 장개빈. 경악전서. 서울: 한미의학; 2006, p. 1469-86.
  21. 왕도. 외대비요방. 상해: 上海古籍出版社; 1993, p. 333-61.
  22. 왕청임. 의림개착. 익산:원광대학교출판국; 1998, p. 89-96, 168.
  23. 周本善. 血府逐瘀湯의 새로운 임상응용. 東洋醫學. 2002:28(1):43-7.
  24. 고승희, 전찬용, 박종형, 한양희, 김동우, 박세기 등. 도인, 소목이 endotoxin으로 유발된 어혈병태모델에 미치는 영향. 대한한방내과학회지 2001; 22(1):39-44.
  25. 김영선, 박종형, 한양희 전찬용, 김동우, 박세기 등. 혈부축어탕이 혈전생성관여인자에 미치는 영향. 대한한방내과학회지 2000;21(5):819-27.
  26. 두호경. 동의신계학. 서울: 성보사; 2003, p. 443-4, 915.
  27. Ginsberg JS. Management of venous thromboembolism. N Engl J Med. 1996 Dec 12;335(24):1816-28. https://doi.org/10.1056/NEJM199612123352407