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Effect of pH-dependent Solubility on Release Behavior of Alginate-Chitosan Blend Containing Activated Carbon

  • Oh, Ae-Ri (Department of Fine Chemical Engineering and Applied Chemistry, BK21-E2M, Chungnam National University) ;
  • Jin, Dong-Hwee (Department of Fine Chemical Engineering and Applied Chemistry, BK21-E2M, Chungnam National University) ;
  • Yun, Ju-Mi (Department of Fine Chemical Engineering and Applied Chemistry, BK21-E2M, Chungnam National University) ;
  • Lee, Young-Seak (Department of Fine Chemical Engineering and Applied Chemistry, BK21-E2M, Chungnam National University) ;
  • Kim, Hyung-Il (Department of Fine Chemical Engineering and Applied Chemistry, BK21-E2M, Chungnam National University)
  • Received : 2009.06.16
  • Accepted : 2009.08.25
  • Published : 2009.09.30
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Abstract

Alginate-chitosan blend containing coconut-based activated carbon was prepared as a drug delivery carrier in order to improve the loading and releasing capacity of the drug. The activated carbon was incorporated as effective adsorbent for drug due to the extremely high surface area and pore volume, high adsorption capacity, micro porous structure and specific surface activity. Alginate-chitosan blend containing coconut-based activated carbon showed the sustained release for a longer period. Alginate-chitosan blend showed higher release of drug as the pH increased and higher release of drug as the content of chitosan decreased due to the pH-dependent solubility of blend components.

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References

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